Alpha/Beta TCD HCT in Patients With Inherited BMF Disorders (NCT03579875)
MT2017-17:T Cell Receptor Alpha/Beta T Cell Depleted Hematopoietic Cell Transplantation in Patients With Inherited Bone Marrow Failure (BMF) Disorders
๐ฉบ Plain-English Summary (8th-Grade Level)
This is a phase II trial of T cell receptor alpha/beta depletion (ฮฑ/ฮฒ TCD) peripheral blood stem cell (PBSC) transplantation in patients with inherited bone marrow failure (BMF) disorders to eliminate the need for routine graft-versus-host disease (GVHD) immune suppression leading to earlier immune recovery and potentially a reduction in the risk of severe infections after transplantation.
Who can join: Review the eligibility criteria below.
Location: Masonic Cancer Center at University of Minnesota โ Minneapolis, Minnesota
Age range: Not specified to 65 Years
๐งช Interventions in This Study
- Total Body Irradiation (TBI) (Plan 1) (DRUG)
- Cyclophosphamide (CY) (Plan 1) (DRUG)
- Fludarabine (FLU) (DRUG)
- Methylprednisolone (MP) (DRUG)
- Donor mobilized PBSC infusion (DEVICE)
- G-CSF (DRUG)
- Cyclophosphamide (CY) (Plan 2) (DRUG)
- Rituximab (DRUG)
- Busulfan (DRUG)
- Alemtuzumab (DRUG)
- Melphalan (DRUG)
- Rituximab (DRUG)
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (1 Sites)
- Masonic Cancer Center at University of Minnesota โ Minneapolis, Minnesota
๐ Contact the Study Coordinator
Phone: (612) 626-2961
Email: macmi002@umn.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.