๐๏ธ Verified NIH Record โข Updated 2026-08-17
Study of AZD9833 Alone or in Combination in Women With Advanced Breast Cancer. (NCT03616587)
A Phase 1 Dose Escalation and Expansion Study of AZD9833 Alone or in Combination in Women With ER-positive, HER2-negative Advanced Breast Cancer (SERENA-1)
๐ต Active, Not Recruiting Phase1 ๐ Investigational Drug / Biologic Sponsor: AstraZeneca
๐ฉบ Plain-English Summary (8th-Grade Level)
A Phase 1 Dose Escalation and Expansion Study of AZD9833 Alone or in Combination in Women with ER Positive, HER2 Negative Advanced Breast Cancer (SERENA-1)
Who can join: Review the eligibility criteria below.
Location: Research Site โ Aurora, Colorado
Age range: 18 Years to 130 Years
๐งช Interventions in This Study
- AZD9833 (DRUG)
- AZD9833 (DRUG)
- AZD9833 with palbociclib (DRUG)
- AZD9833 with palbociclib (DRUG)
- AZD9833 with everolimus (DRUG)
- AZD9833 with everolimus (DRUG)
- AZD9833 with abemaciclib (DRUG)
- AZD9833 with abemaciclib (DRUG)
- AZD9833 with capivasertib (DRUG)
- AZD9833 with capivasertib (DRUG)
- AZD9833 with ribociclib (DRUG)
- AZD9833 with ribociclib (DRUG)
- AZD9833 with anastrozole (DRUG)
- AZD9833 with anastrozole (DRUG)
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (17 Sites)
- Research Site โ Aurora, Colorado
- Research Site โ Sarasota, Florida
- Research Site โ Philadelphia, Pennsylvania
- Research Site โ Nashville, Tennessee
- Research Site โ Salt Lake City, Utah
- Research Site โ Barcelona,
- Research Site โ Barcelona,
- Research Site โ Madrid,
- Research Site โ Madrid,
- Research Site โ Seville,
- Research Site โ Valencia,
- Research Site โ Cambridge,
- Research Site โ Leeds,
- Research Site โ London,
- Research Site โ Manchester,
- Research Site โ Sutton,
- Research Site โ Sutton,
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.