๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-05-28

The LATITUDE Study: Long-Acting Therapy to Improve Treatment SUccess in Daily LifE (NCT03635788)

A Phase III Study to Evaluate Long-Acting Antiretroviral Therapy in Non-Adherent HIV-Infected Individuals

๐Ÿ”ต Active, Not Recruiting Phase3 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

The purpose of this study was to compare the efficacy, safety, and durability of two different strategies to treat participants with a history of sub-optimal adherence and control of their HIV infection: long-acting (LA) antiretroviral therapy (ART) and all-oral standard of care (SOC).

Who can join: Review the eligibility criteria below.

Location: Alabama CRS โ€” Birmingham, Alabama

Age range: 18 Years

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (33 Sites)

Showing the first 25 of 33 sites.

  • Alabama CRS โ€” Birmingham, Alabama
  • University of Southern California CRS โ€” Los Angeles, California
  • UCLA CARE Center CRS โ€” Los Angeles, California
  • UCSD Antiviral Research Center CRS โ€” San Diego, California
  • Ucsf Hiv/Aids Crs โ€” San Francisco, California
  • Harbor-UCLA CRS โ€” Torrance, California
  • University of Colorado Hospital CRS โ€” Aurora, Colorado
  • Univ. of Florida Jacksonville NICHD CRS โ€” Jacksonville, Florida
  • The Ponce de Leon Center CRS โ€” Atlanta, Georgia
  • Northwestern University CRS โ€” Chicago, Illinois
  • Rush University CRS โ€” Chicago, Illinois
  • Johns Hopkins University CRS โ€” Baltimore, Maryland
  • Massachusetts General Hospital CRS (MGH CRS) โ€” Boston, Massachusetts
  • Brigham and Women's Hospital Therapeutics Clinical Research Site (BWH TCRS) CRS โ€” Boston, Massachusetts
  • Washington University Therapeutics (WT) CRS โ€” St Louis, Missouri
  • New Jersey Medical School Clinical Research Center CRS โ€” Newark, New Jersey
  • Weill Cornell Chelsea CRS โ€” New York, New York
  • Columbia P&S CRS โ€” New York, New York
  • Weill Cornell Uptown CRS โ€” New York, New York
  • SUNY Stony Brook NICHD CRS โ€” Stony Brook, New York
  • Jacobi Med. Ctr. Bronx NICHD CRS โ€” The Bronx, New York
  • Chapel Hill CRS โ€” Chapel Hill, North Carolina
  • Greensboro CRS โ€” Greensboro, North Carolina
  • Cincinnati Clinical Research Site โ€” Cincinnati, Ohio
  • Case Clinical Research Site โ€” Cleveland, Ohio

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All HIV Infections clinical trials

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—