Dose-escalation and Dose-expansion Study of Safety of Azer-cel (PBCAR0191) in Participants With Relapsed/Refractory (r/r) Non-Hodgkin Lymphoma (NHL) and r/r B-cell Acute Lymphoblastic Leukemia (B-ALL) (NCT03666000)
A Phase 1/1b, Open-label, Dose-escalation, Dose-expansion, Parallel Assignment Study to Evaluate Safety and Clinical Activity of PBCAR0191 (Azercabtagene Zapreleucel or "Azer-cel") in Subjects With Relapsed/Refractory (r/r) Non-Hodgkin Lymphoma (NHL) and r/r B-cell Acute Lymphoblastic Leukemia (B-ALL)
🩺 Plain-English Summary (8th-Grade Level)
This is a Phase 1/1b, nonrandomized, open-label, parallel assignment, dose-escalation, and dose-expansion study to evaluate the safety and clinical activity of azer-cel, an allogeneic anti-CD19 CAR T, in adults with r/r B ALL, r/r B-cell NHL and CLL/SLL.
Who can join: Review the eligibility criteria below.
Location: Banner MD Anderson Cancer Center — Gilbert, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (23 Sites)
- Banner MD Anderson Cancer Center — Gilbert, Arizona
- City of Hope — Duarte, California
- H. Lee Moffitt Cancer Center — Tampa, Florida
- Winship Cancer Institute Emory University — Atlanta, Georgia
- Northside Hospital Cancer Institute — Atlanta, Georgia
- University of Maryland — Baltimore, Maryland
- Tufts Medical Center — Boston, Massachusetts
- Dana-Farber Cancer Institute — Boston, Massachusetts
- Barbara Ann Karmanos Cancer Institute (Wayne State University) — Detroit, Michigan
- University of Minnesota — Minneapolis, Minnesota
- Weill Cornell Medical College - NY Presbyterian Hospital — New York, New York
- Columbia University Irving Medical Center/New York Presbyterian Hospital — New York, New York
- Duke University — Durham, North Carolina
- Ohio State University — Columbus, Ohio
- Lifespan Cancer Institute at Rhode Island Hospital — Providence, Rhode Island
- Baylor University Medical Center — Dallas, Texas
- MD Anderson — Houston, Texas
- Medical College of Wisconsin — Milwaukee, Wisconsin
- Royal Prince Alfred Hospital — Camperdown, New South Wales
- Liverpool Hospital — Liverpool, New South Wales
- Royal Adelaide Hospital — Adelaide, South Australia
- St Vincent's Hospital Melbourne — Fitzroy, Victoria
- Barwon Health - Andrew Love Cancer Centre — Geelong, Victoria
📞 Contact the Study Coordinator
Phone: (984) 245-0082
Email: info@imugene.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Non-Hodgkin Lymphoma
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- A Study to Evaluate Adverse Events and Change in Disease Activity of Subcutaneous (SC) Epcoritamab in Combination With Oral and Intravenous Anti-Neoplastic Agents in Adult Participants With Non-Hodgkin Lymphoma — Tucson, Arizona
- A Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab Monotherapy in Participants With Select B-Cell Malignancies — Mobile, Alabama
- AntiCD19 Chimeric Antigen Receptor T Cells for Relapsed or Refractory Non Hodgkin Lymphoma — St Louis, Missouri
- Radiation Dose Study for Relapsed/Refractory Hodgkin/Non-Hodgkin Lymphoma — Chicago, Illinois
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Explore by condition: All Non-Hodgkin Lymphoma clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.