🏛️ Verified NIH Record • Updated 2026-06-05
Cancer Driving Mutations in Endometriosis Lesions and Development of Progesterone Resistance (NCT03756480)
Prospective Clinical Study of the Relationship Between Cancer Driving Mutations Found in Endometriotic Implants and the Development of Progesterone Resistance
🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research Sponsor: Johns Hopkins University
🩺 Plain-English Summary (8th-Grade Level)
This study will test the hypothesis that the molecular changes present in ectopic endometriosis lesions correlate with progesterone-resistant disease (using the criteria defined in this study) and are present in matched eutopic endometrium.
Who can join: Review the eligibility criteria below.
Location: Yale School of Medicine — New Haven, Connecticut
Age range: 18 Years to 45 Years
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (3 Sites)
- Yale School of Medicine — New Haven, Connecticut
- Johns Hopkins Hospital — Baltimore, Maryland
- Vanderbilt University Medical Center — Nashville, Tennessee
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Endometriosis
- Nutritional Intervention for Endometriosis — Washington D.C., District of Columbia
- Evaluation of Endometriosis With 18F-fluorofuranylnorprogesterone PET / MRI — Chapel Hill, North Carolina
- Study Of Oral Elagolix Tablets In Combination With Combined Oral Contraceptive Capsules/Tablets To Assess Dysmenorrhea Response In Adult Female Participants With Endometriosis And Associated Moderate To Severe Pain — Anniston, Alabama
- The EMPOWER Study: Endometriosis Diagnosis Using MicroRNA — Palo Alto, California
- Endometriosis and Health Care System Utilization in British Columbia — Vancouver, British Columbia
Explore by condition: All Endometriosis clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.