🏛️ Verified NIH Record • Updated 2026-04-21

Osimertinib Plus Savolitinib in EGFRm+/MET+ NSCLC Following Prior Osimertinib (NCT03778229)

A Phase II Study Assessing the Efficacy of Osimertinib in Combination With Savolitinib in Patients With EGFRm+ and MET+, Locally Advanced or Metastatic Non Small Cell Lung Cancer Who Have Progressed Following Treatment With Osimertinib.

🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: AstraZeneca

🩺 Plain-English Summary (8th-Grade Level)

This study (the SAVANNAH study) will investigate the efficacy of osimertinib in combination with savolitinib in patients with EGFRm+ and MET+, locally advanced or metastatic NSCLC who have progressed following treatment with osimertinib

Who can join: Review the eligibility criteria below.

Location: Research Site — La Jolla, California

Age range: 18 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (90 Sites)

Showing the first 25 of 90 sites.

  • Research Site — La Jolla, California
  • Research Site — Los Angeles, California
  • Research Site — Sacramento, California
  • Research Site — Washington D.C., District of Columbia
  • Research Site — Baltimore, Maryland
  • Research Site — Boston, Massachusetts
  • Research Site — Rochester, Minnesota
  • Research Site — Brooklyn, New York
  • Research Site — Philadelphia, Pennsylvania
  • Research Site — Pittsburgh, Pennsylvania
  • Research Site — Seattle, Washington
  • Research Site — Barretos,
  • Research Site — Curitiba,
  • Research Site — Goiânia,
  • Research Site — Porto Alegre,
  • Research Site — Porto Alegre,
  • Research Site — Rio de Janeiro,
  • Research Site — Salvador,
  • Research Site — São José do Rio Preto,
  • Research Site — São Paulo,
  • Research Site — São Paulo,
  • Research Site — Calgary, Alberta
  • Research Site — Edmonton, Alberta
  • Research Site — Newmarket, Ontario
  • Research Site — North York, Ontario

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Carcinoma clinical trials

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗