Safety and Efficacy of Quizartinib in Children and Young Adults With Acute Myeloid Leukemia (AML), a Cancer of the Blood (NCT03793478)
A Phase 1/2, Multicenter, Dose-Escalating Study To Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy Of Quizartinib Administered in Combination With Re-Induction Chemotherapy, and as a Single-Agent Continuation Therapy, in Pediatric Relapsed/Refractory AML Subjects Aged 1 Month to <18 Years (and Young Adults Aged up to 21 Years) With FLT3-ITD Mutations
🩺 Plain-English Summary (8th-Grade Level)
Quizartinib is an experimental drug. It is not approved for regular use. It can only be used in medical research. Children or young adults with a certain kind of blood cancer (FLT3-ITD AML) might be able to join this study if it has come back after remission or is not responding to treatment.
Who can join: Review the eligibility criteria below.
Location: Loma Linda University Cancer Center — Loma Linda, California
Age range: 1 Month to 21 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (27 Sites)
Showing the first 25 of 27 sites.
- Loma Linda University Cancer Center — Loma Linda, California
- University of California, San Francisco — San Francisco, California
- Children's Hospital Colorado — Aurora, Colorado
- A.I. duPont Hospital for Children — Wilmington, Delaware
- Children's National Medical Center — Washington D.C., District of Columbia
- Children's Healthcare of Atlanta — Atlanta, Georgia
- University of Minnesota/Masonic Cancer Center — Minneapolis, Minnesota
- Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio
- UPMC Children's Hospital of Pittsburgh — Pittsburgh, Pennsylvania
- The University of Texas Southwestern Medical Center Children's Health — Dallas, Texas
- Seattle Children's Hospital — Seattle, Washington
- Universitair Ziekenhuis Gent — Ghent,
- The Hospital for Sick Children — Toronto, Ontario
- British Columbia Children's Hospital — Vancouver,
- Rigshospitalet — Copenhagen,
- Centre Léon Bérard — Lyon,
- Hôpital Armand-Trousseau — Paris,
- Hôpital des Enfants — Toulouse,
- Rambam Medical Center — Haifa,
- Tel Aviv Sourasky Medical Center — Tel Aviv,
- Fondazione IRCCS San Gerardo dei Tintori — Monza,
- IRCCS Ospedale Pediatrico Bambino Gesù — Rome,
- Ospedale Infantile Regina Margherita — Torino,
- Prinses Maxima Centrum voor Kinderoncologie — Utrecht,
- Hospital Infantil Universitario Nino Jesus — Madrid,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Acute Myeloid Leukemia
- PRGN-3006 Adoptive Cellular Therapy for CD33-Positive Relapsed or Refractory AML, MRD Positive AML or Higher Risk MDS — Tampa, Florida
- Gamma Delta T-cell Infusion for AML at High Risk of Relapse After Allo HCT — Tampa, Florida
- Daunorubicin and Cytarabine With or Without Uproleselan in Treating Older Adult Patients With Acute Myeloid Leukemia Receiving Intensive Induction Chemotherapy — Little Rock, Arkansas
- Azacitidine and Gemtuzumab Ozogamicin in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia — Burbank, California
- A Study to Assess Safety, Tolerability and Preliminary Efficacy of Bexmarilimab in Combination With Standard of Care in Patients With Hematological Malignancies — Duarte, California
- A Trial of Epigenetic Priming in Patients With Newly Diagnosed Acute Myeloid Leukemia — Madera, California
Explore by condition: All Acute Myeloid Leukemia clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.