🏛️ Verified NIH Record • Updated 2026-07-20
Linaclotide in Treating Patients With Stages 0-3 Colorectal Cancer (NCT03796884)
Phase II Randomized, Placebo-Controlled Trial of Linaclotide to Demonstrate Bioactivity in Patients With Sporadic Colorectal Adenomas and With Colorectal Cancer
🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
🩺 Plain-English Summary (8th-Grade Level)
This phase II trial studies the how well linaclotide works in treating patients with stages 0-3 colorectal cancer. Linaclotide is a very small protein that binds to receptors on intestinal cells and makes them secrete water and salt.
Who can join: Review the eligibility criteria below.
Location: Fox Chase Cancer Center — Philadelphia, Pennsylvania
Age range: 18 Years to 80 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (3 Sites)
- Fox Chase Cancer Center — Philadelphia, Pennsylvania
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University — Philadelphia, Pennsylvania
- VA Puget Sound Health Care Sysem — Seattle, Washington
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Colorectal Adenoma
- Aspirin in Preventing Colorectal Cancer in Patients With Colorectal Adenoma — Nashville, Tennessee
- Vaccine Therapy in Treating Patients With Newly Diagnosed Advanced Colon Polyps — Boston, Massachusetts
- Evaluation of Gixam's Performance in a FIT Negative Population — Portland, Oregon
Explore by condition: All Colorectal Adenoma clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.