🏛️ Verified NIH Record • Updated 2025-12-08
A Study of Salvage Radiotherapy With or Without Enzalutamide in Recurrent Prostate Cancer Following Surgery (NCT03809000)
STEEL: A Randomized Phase II Trial of Salvage Radiotherapy With Standard vs Enhanced Androgen Deprivation Therapy (With Enzalutamide) in Patients With Post-Prostatectomy PSA Recurrences With Aggressive Disease Features
🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: RTOG Foundation, Inc.
🩺 Plain-English Summary (8th-Grade Level)
Patients with post-prostatectomy PSA (Prostate Specific Antigen) recurrences with aggressive disease features will receive salvage radiation therapy and standard androgen deprivation therapy (ADT) or enhanced ADT to determine if there is any improvement in progression-free survival when enhanced ADT is used compared to standard ADT.
Who can join: Review the eligibility criteria below.
Location: Arizona Center for Cancer Care - Gilbert — Gilbert, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (108 Sites)
Showing the first 25 of 108 sites.
- Arizona Center for Cancer Care - Gilbert — Gilbert, Arizona
- Arizona Center for Cancer Care - Peoria — Peoria, Arizona
- Arizona Center for Cancer Care - Phoenix — Phoenix, Arizona
- Arizona Center for Cancer Care - Scottsdale East — Scottsdale, Arizona
- Arizona Center for Cancer Care - Scottsdale North — Scottsdale, Arizona
- Arizona Center for Cancer Care - Surprise — Surprise, Arizona
- Marin Cancer Care, Inc. — Greenbrae, California
- Marin Health Medical Center — Greenbrae, California
- University of Southern California — Los Angeles, California
- USC Medical Center - Los Angeles County — Los Angeles, California
- Cedars-Sinai Medical Center — Los Angeles, California
- Roseville Radiation Oncology Center — Roseville, California
- Sutter Roseville Medical Center — Roseville, California
- Sutter Medical Center Sacramento — Sacramento, California
- University of California, San Francisco — San Francisco, California
- Valley View Hospital Cancer Center — Glenwood Springs, Colorado
- University of Florida Health Science Center — Gainesville, Florida
- AdventHealth Orlando — Orlando, Florida
- Moffitt Cancer Center — Tampa, Florida
- Nancy N. & J.C. Lewis Cancer & Research Pavilion — Savannah, Georgia
- Rush University Medical Center — Chicago, Illinois
- Decatur Memorial Hospital — Decatur, Illinois
- Crossroads Cancer Center — Effingham, Illinois
- Loyola University Medical Center — Maywood, Illinois
- University of Kansas Cancer Center — Kansas City, Kansas
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Prostate Cancer
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- A Study in Which Non-metastatic Castration-resistant Prostate Cancer (nmCRPC) Patients for Whom a Decision to Treat With Darolutamide Has Been Made Before Enrollment Are Observed and Certain Outcomes Are Described — Homewood, Alabama
- Stereotactic Ablative Radiation Therapy for Prostate Cancer — Charleston, South Carolina
- A Study of Stereotactic Body Radiation Therapy (SBRT) Without Androgen Deprivation Therapy (ADT) in People With Unfavorable Intermediate-Risk Prostate Cancer — Basking Ridge, New Jersey
- A Study of Abiraterone Acetate Plus Prednisone With or Without Abemaciclib (LY2835219) in Participants With Prostate Cancer — Phoenix, Arizona
- Neoadjuvant Enoblituzumab (MGA271) in Men With Localized Intermediate and High-Risk Prostate Cancer — Baltimore, Maryland
Explore by condition: All Prostate Cancer clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.