๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2025-11-18

Larotrectinib in Treating Patients With Previously Untreated TRK Fusion Solid Tumors and TRK Fusion Relapsed Acute Leukemia (NCT03834961)

Larotrectinib (LOXO-101, NSC# 788607) for Previously Untreated TRK Fusion Pediatric Solid Tumors and TRK Fusion Relapsed Pediatric Acute Leukemias

๐Ÿ”ต Active, Not Recruiting Phase2 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Children's Oncology Group

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

This phase II trial studies the side effects and how well larotrectinib works in treating patients with previously untreated TRK fusion solid tumors and TRK fusion acute leukemia that has come back. Larotrectinib may stop the growth of cancer cells with TRK fusions by blocking the TRK enzymes needed for cell growth.

Who can join: Review the eligibility criteria below.

Location: Children's Hospital of Alabama โ€” Birmingham, Alabama

Age range: Not specified to 30 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (80 Sites)

Showing the first 25 of 80 sites.

  • Children's Hospital of Alabama โ€” Birmingham, Alabama
  • Arkansas Children's Hospital โ€” Little Rock, Arkansas
  • Kaiser Permanente Downey Medical Center โ€” Downey, California
  • Children's Hospital Los Angeles โ€” Los Angeles, California
  • Kaiser Permanente-Oakland โ€” Oakland, California
  • Children's Hospital of Orange County โ€” Orange, California
  • UCSF Medical Center-Mission Bay โ€” San Francisco, California
  • Children's Hospital Colorado โ€” Aurora, Colorado
  • Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center โ€” Denver, Colorado
  • Yale University โ€” New Haven, Connecticut
  • Alfred I duPont Hospital for Children โ€” Wilmington, Delaware
  • MedStar Georgetown University Hospital โ€” Washington D.C., District of Columbia
  • Children's National Medical Center โ€” Washington D.C., District of Columbia
  • Broward Health Medical Center โ€” Fort Lauderdale, Florida
  • Golisano Children's Hospital of Southwest Florida โ€” Fort Myers, Florida
  • University of Florida Health Science Center - Gainesville โ€” Gainesville, Florida
  • Nemours Children's Clinic-Jacksonville โ€” Jacksonville, Florida
  • University of Miami Miller School of Medicine-Sylvester Cancer Center โ€” Miami, Florida
  • Nicklaus Children's Hospital โ€” Miami, Florida
  • Nemours Children's Hospital โ€” Orlando, Florida
  • Saint Joseph's Hospital/Children's Hospital-Tampa โ€” Tampa, Florida
  • Children's Healthcare of Atlanta - Arthur M Blank Hospital โ€” Atlanta, Georgia
  • Kapiolani Medical Center for Women and Children โ€” Honolulu, Hawaii
  • Saint Luke's Cancer Institute - Boise โ€” Boise, Idaho
  • Saint Jude Midwest Affiliate โ€” Peoria, Illinois

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—