Durvalumab and Tremelimumab for Pediatric Malignancies (NCT03837899)
Phase I/II, Open-Label Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of Durvalumab Monotherapy or in Combination With Tremelimumab in Pediatric Patients With Advanced Solid Tumors and Hematological Malignancies.
🩺 Plain-English Summary (8th-Grade Level)
The purpose of the study is to determine the recommended dose of durvalumab and tremelimumab (immunotherapy drugs) in pediatric patients with advanced solid and hematological cancers and expand in a second phase to test the efficacy of these drugs once this dose is determined.
Who can join: Review the eligibility criteria below.
Location: Research Site — Baltimore, Maryland
Age range: 0 Years to 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (19 Sites)
- Research Site — Baltimore, Maryland
- Research Site — Boston, Massachusetts
- Research Site — New Hyde Park, New York
- Research Site — Oklahoma City, Oklahoma
- Research Site — Charleston, South Carolina
- Research Site — Lille,
- Research Site — Marseille,
- Research Site — Paris,
- Research Site — Cologne,
- Research Site — Genova,
- Research Site — Milan,
- Research Site — Rome,
- Research Site — Torino,
- Research Site — Utrecht,
- Research Site — Barcelona,
- Research Site — Madrid,
- Research Site — Leeds,
- Research Site — London,
- Research Site — Sutton,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.