๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-08-21

Preventing Alzheimer's With Cognitive Training (NCT03848312)

Cognitive Training to Reduce Incidence of Cognitive Impairment in Older Adults

๐Ÿ”ต Active, Not Recruiting Phase3 ๐Ÿง  Behavioral & Psychological Program Sponsor: University of South Florida

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

Dementia is the most expensive medical condition in the US and increases in prevalence with age. More than 5 million Americans have Alzheimer's disease, the most common form of dementia. Mild cognitive impairment is a transitional stage between normal cognitive aging and Alzheimer's disease or another type of dementia, and is indicative of higher risk for dementia. In addition to the obvious health and quality-of-life ramifications of dementia, there are high direct (e.g., subsidizing residential care needs) and indirect (e.g., lost productivity of family caregivers) economic costs. Implementing interventions to prevent MCI and dementia among older adults is of critical importance to health and maintained quality-of-life for millions of Americans. Recent data analyses from the Advanced Cognitive Training in Vital Elderly study (ACTIVE) indicate that a specific cognitive intervention, speed of processing training (SPT), significantly delays the incidence of cognitive impairment across 10 years. The primary contribution of the proposed research will be the determination of whether this cognitive training technique successfully delays the onset of clinically defined MCI or dementia across three years.

Who can join: Review the eligibility criteria below.

Location: University of Florida โ€” Gainesville, Florida

Age range: 65 Years

๐Ÿงช Interventions in This Study

  • Cognitive Training (BEHAVIORAL)
  • Computerized Cognitive Stimulation (BEHAVIORAL)

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (7 Sites)

  • University of Florida โ€” Gainesville, Florida
  • University of Florida โ€” Jacksonville, Florida
  • University of North Florida โ€” Jacksonville, Florida
  • The Roskamp Institute โ€” Sarasota, Florida
  • University of South Florida โ€” Tampa, Florida
  • Duke Health โ€” Durham, North Carolina
  • Clemson University Institute for Engaged Aging โ€” Seneca, South Carolina

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

More studies in Age-related Cognitive Decline

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—