Who is eligible for clinical trial NCT03875235?

Participants must meet protocol criteria for Biliary Tract Neoplasms. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT03875235 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-08-21

Durvalumab or Placebo in Combination With Gemcitabine/Cisplatin in Patients With 1st Line Advanced Biliary Tract Cancer (TOPAZ-1) (NCT03875235)

A Phase III Randomized, Double-Blind Placebo Controlled, Multi-Regional, International Study of Durvalumab in Combination With Gemcitabine Plus Cisplatin Versus Placebo in Combination With Gemcitabine Plus Cisplatin for Patients With First-Line Advanced Biliary Tract Cancers

🔵 Active, Not Recruiting Phase3 💊 Investigational Drug / Biologic Sponsor: AstraZeneca

🩺 Plain-English Summary (8th-Grade Level)

Durvalumab or Placebo in Combination With Gemcitabine/Cisplatin in Patients With 1st Line Advanced Biliary Tract Cancer (TOPAZ-1).

Who can join: Review the eligibility criteria below.

Location: Research Site — Los Angeles, California

Age range: 18 Years to 130 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (126 Sites)

Showing the first 25 of 126 sites.

Research Site — Los Angeles, California
Research Site — Orange, California
Research Site — Washington D.C., District of Columbia
Research Site — Fort Myers, Florida
Research Site — St. Petersburg, Florida
Research Site — Westwood, Kansas
Research Site — Louisville, Kentucky
Research Site — Burlington, Massachusetts
Research Site — St Louis, Missouri
Research Site — Chapel Hill, North Carolina
Research Site — Portland, Oregon
Research Site — Philadelphia, Pennsylvania
Research Site — Chattanooga, Tennessee
Research Site — Nashville, Tennessee
Research Site — Seattle, Washington
Research Site — Buenos Aires,
Research Site — CABA,
Research Site — CABA,
Research Site — Ciudad de Buenos Aires,
Research Site — Ciudad de Buenos Aires,
Research Site — Rosario,
Research Site — San Salvador de Jujuy,
Research Site — Burgas,
Research Site — Sofia,
Research Site — Sofia,

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Biliary Tract Neoplasms clinical trials

💡 How to Participate

Check the checklist above to see if you may qualify.
Review the official NIH record below to find the coordinating site.
Ask about the visit schedule, what is covered at no cost, and any travel support.
Confirm with your own doctor before making a decision.

🏛️ View Official NIH Record ↗