A Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ABBV-927 With ABBV-368, Budigalimab (ABBV-181) and/or Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors (NCT03893955)
A Phase 1, Multicenter, Open-Label Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of Combinations of ABBV-927 With ABBV-368, Budigalimab (ABBV-181) and/or Chemotherapy in Subjects With Locally Advanced or Metastatic Solid Tumors
🩺 Plain-English Summary (8th-Grade Level)
A study evaluating the safety, pharmacokinetics (PK), pharmacodynamics, and preliminary efficacy of ABBV-927 with ABBV-368, Budigalimab (ABBV-181) and/or chemotherapy in participants with selected solid tumors. This study consists of 2 main parts, a dose-escalation phase and a dose-expansion phase. The dose-expansion phase can begin once the recommended phase 2 dose/maximum tolerated dose (RP2D/MTD) is determined in the dose-escalation phase.
Who can join: Review the eligibility criteria below.
Location: Highlands Oncology Group, PA /ID# 218863 — Springdale, Arkansas
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (26 Sites)
Showing the first 25 of 26 sites.
- Highlands Oncology Group, PA /ID# 218863 — Springdale, Arkansas
- St Jude Hospital dba St Joseph /ID# 211130 — Santa Rosa, California
- Yale University School of Medicine /ID# 210678 — New Haven, Connecticut
- Moffitt Cancer Center /ID# 215037 — Tampa, Florida
- Fort Wayne Medical Oncology and Hematology, Inc /ID# 226072 — Fort Wayne, Indiana
- Washington University-School of Medicine /ID# 221399 — St Louis, Missouri
- Duke Cancer Center /ID# 217641 — Durham, North Carolina
- Carolina BioOncology Institute /ID# 210664 — Huntersville, North Carolina
- UPMC Hillman Cancer Ctr /ID# 222747 — Pittsburgh, Pennsylvania
- Tennessee Oncology-Nashville Centennial /ID# 221400 — Nashville, Tennessee
- Mary Crowley Cancer Research /ID# 210716 — Dallas, Texas
- NEXT Oncology /ID# 210717 — San Antonio, Texas
- Virginia Cancer Specialists - Fairfax /ID# 210671 — Fairfax, Virginia
- Duplicate_Icon Cancer Centre /ID# 224084 — South Brisbane, Queensland
- Institut de Cancérologie de l'Ouest René Gauducheau /ID# 212880 — Saint-Herblain, Loire-Atlantique
- Institut Curie /ID# 223475 — Paris, Paris
- Centre Leon Berard /ID# 217910 — Lyon, Rhone
- Centre Jean Perrin /ID# 217911 — Clermont-Ferrand,
- AP-HP - Hopital Bichat - Claude-Bernard /ID# 212869 — Paris,
- The Chaim Sheba Medical Center /ID# 211699 — Ramat Gan, Tel Aviv
- Hospital Universitario Vall d'Hebron /ID# 212804 — Barcelona,
- Hospital Universitario Fundacion Jimenez Diaz /ID# 212806 — Madrid,
- Hospital Universitario HM Sanchinarro /ID# 212805 — Madrid,
- Hospital Universitario Virgen de la Victoria /ID# 221671 — Málaga,
- National Taiwan University Hospital /ID# 210993 — Taipei City, Taipei
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.