🏛️ Verified NIH Record • Updated 2025-08-07

A Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ABBV-927 With ABBV-368, Budigalimab (ABBV-181) and/or Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors (NCT03893955)

A Phase 1, Multicenter, Open-Label Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of Combinations of ABBV-927 With ABBV-368, Budigalimab (ABBV-181) and/or Chemotherapy in Subjects With Locally Advanced or Metastatic Solid Tumors

🔵 Active, Not Recruiting Phase1 💊 Investigational Drug / Biologic Sponsor: AbbVie

🩺 Plain-English Summary (8th-Grade Level)

A study evaluating the safety, pharmacokinetics (PK), pharmacodynamics, and preliminary efficacy of ABBV-927 with ABBV-368, Budigalimab (ABBV-181) and/or chemotherapy in participants with selected solid tumors. This study consists of 2 main parts, a dose-escalation phase and a dose-expansion phase. The dose-expansion phase can begin once the recommended phase 2 dose/maximum tolerated dose (RP2D/MTD) is determined in the dose-escalation phase.

Who can join: Review the eligibility criteria below.

Location: Highlands Oncology Group, PA /ID# 218863 — Springdale, Arkansas

Age range: 18 Years

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (26 Sites)

Showing the first 25 of 26 sites.

  • Highlands Oncology Group, PA /ID# 218863 — Springdale, Arkansas
  • St Jude Hospital dba St Joseph /ID# 211130 — Santa Rosa, California
  • Yale University School of Medicine /ID# 210678 — New Haven, Connecticut
  • Moffitt Cancer Center /ID# 215037 — Tampa, Florida
  • Fort Wayne Medical Oncology and Hematology, Inc /ID# 226072 — Fort Wayne, Indiana
  • Washington University-School of Medicine /ID# 221399 — St Louis, Missouri
  • Duke Cancer Center /ID# 217641 — Durham, North Carolina
  • Carolina BioOncology Institute /ID# 210664 — Huntersville, North Carolina
  • UPMC Hillman Cancer Ctr /ID# 222747 — Pittsburgh, Pennsylvania
  • Tennessee Oncology-Nashville Centennial /ID# 221400 — Nashville, Tennessee
  • Mary Crowley Cancer Research /ID# 210716 — Dallas, Texas
  • NEXT Oncology /ID# 210717 — San Antonio, Texas
  • Virginia Cancer Specialists - Fairfax /ID# 210671 — Fairfax, Virginia
  • Duplicate_Icon Cancer Centre /ID# 224084 — South Brisbane, Queensland
  • Institut de Cancérologie de l'Ouest René Gauducheau /ID# 212880 — Saint-Herblain, Loire-Atlantique
  • Institut Curie /ID# 223475 — Paris, Paris
  • Centre Leon Berard /ID# 217910 — Lyon, Rhone
  • Centre Jean Perrin /ID# 217911 — Clermont-Ferrand,
  • AP-HP - Hopital Bichat - Claude-Bernard /ID# 212869 — Paris,
  • The Chaim Sheba Medical Center /ID# 211699 — Ramat Gan, Tel Aviv
  • Hospital Universitario Vall d'Hebron /ID# 212804 — Barcelona,
  • Hospital Universitario Fundacion Jimenez Diaz /ID# 212806 — Madrid,
  • Hospital Universitario HM Sanchinarro /ID# 212805 — Madrid,
  • Hospital Universitario Virgen de la Victoria /ID# 221671 — Málaga,
  • National Taiwan University Hospital /ID# 210993 — Taipei City, Taipei

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

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💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗