🏛️ Verified NIH Record • Updated 2025-02-27
Benzodiazepine-free Cardiac Anesthesia for Reduction of Postoperative Delirium (NCT03928236)
🔵 Active, Not Recruiting Observational / Diagnostic 📋 Clinical Research Protocol Sponsor: Population Health Research Institute
🩺 Plain-English Summary (8th-Grade Level)
B-FREE is a pragmatic, multicentre, cluster crossover trial evaluating whether a policy limiting the use of intra-operative benzodiazepine reduces post-operative delirium when compared with a policy of 'ad libitum' administration. The knowledge generated by this study will provide the basis for cardiac anesthesia practice guidelines.
Who can join: Review the eligibility criteria below.
Location: Washington University School of Medicine — St Louis, Missouri
Age range: 18 Years
🧪 Interventions in This Study
- Limited Intraoperative Benzodiazepine (OTHER)
- Liberal Intraoperative Benzodiazepine (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (20 Sites)
- Washington University School of Medicine — St Louis, Missouri
- Weill Cornell Medicine — New York, New York
- Mazankowski Alberta Heart Institute — Edmonton, Alberta
- Royal Columbian Hospital — New Westminster, British Columbia
- Vancouver General Hospital — Vancouver, British Columbia
- St. Paul's Hospital — Vancouver, British Columbia
- St. Boniface General Hospital — Winnipeg, Manitoba
- Queen Elizabeth II Health Sciences Centre — Halifax, Nova Scotia
- Hamilton Health Sciences, Hamilton General Hospital — Hamilton, Ontario
- Kingston General Hospital — Kingston, Ontario
- London Health Sciences Centre — London, Ontario
- Sunnybrook Health Sciences Centre — Toronto, Ontario
- St. Michael's Hospital — Toronto, Ontario
- Toronto General Hospital — Toronto, Ontario
- Montreal Heart Institute — Montreal, Quebec
- Jewish General Hospital — Montreal, Quebec
- Hôpital Laval — Québec, Quebec
- Centre Hospitalier Universitaire de Sherbrooke — Sherbrooke, Quebec
- Regina General Hospital — Regina, Saskatchewan
- Royal University Hospital — Saskatoon, Saskatchewan
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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Explore by condition: All Delirium clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.