The Renin-Angiotensin-Aldosterone System in Adiposity, Blood Pressure and Glucose in African Americans (NCT03938389)
The Role of the Renin-Angiotensin-Aldosterone System in Adiposity, Blood Pressure and Glucose Metabolism Among African Americans: Pilot Study
🩺 Plain-English Summary (8th-Grade Level)
The primary objective is to examine the impact of the Renin-Angiotensin-Aldosterone System (RAAS) blockade with medications (valsartan) or RAAS and neprilysin inhibition (valsartan/sacubitril) vs. placebo on changes in blood sugar and insulin secretion from the pancreas over 26 weeks assessed with glucose clamp studies among African Americans (AAs) with impaired glucose tolerance. The investigators hypothesize that combined RAAS/neprilysin inhibition will lead to greater improvement in insulin release from the pancreas and improved blood sugar compared to RAAS inhibition alone among AAs with impaired glucose tolerance.
Who can join: Review the eligibility criteria below.
Location: The Ohio State University Wexner Medical Center — Columbus, Ohio
Age range: 18 Years to 65 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- The Ohio State University Wexner Medical Center — Columbus, Ohio
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in PreDiabetes
- Randomized Trial of Exercise Promotion in Primary Care — Pasadena, California
- Monounsaturated Fatty Acid Supplementation for Overweight and Obese Individuals With Prediabetes — Boston, Massachusetts
- Pharmacists' Delivery of Education to Prevent Diabetes in the New Orleans Hospitality Industry — New Orleans, Louisiana
- Assessing Gut Microbiota Mediated Health Outcomes of Whole Wheat and Its Major Bioactive Components — Columbus, Ohio
- Behavioral Nudges for Diabetes Prevention (BEGIN) Trial in Primary Care — Chicago, Illinois
- The YMCA Healthy Lifestyle Program for Prediabetes — Port Huron, Michigan
Explore by condition: All PreDiabetes clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.