🏛️ Verified NIH Record • Updated 2025-09-04
Hormonal Mechanisms of Sleep Restriction - Axis Study in Older Men and Postmenopausal Women (NCT04037605)
🔵 Active, Not Recruiting Early Phase1 💊 Investigational Drug / Biologic Sponsor: Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to 1) determine how hypothalamic-pituitary-adrenal axis (HPA axis) activation occurs with sleep restriction and 2) evaluate how hypothalamic-pituitary-gonadal axis (HPG axis) deactivation occurs with sleep restriction. The investigator will also examine the cognitive function associated with sleep restriction, including food intake and food cravings.
Who can join: Review the eligibility criteria below.
Location: Los Angeles Biomedical Research Institute — Torrance, California
Age range: 60 Years to 80 Years
🧪 Interventions in This Study
- Ketoconazole Pill (also known as nizoral) (DRUG)
- Ganirelix (DRUG)
- Dexamethasone Pill (DRUG)
- Dexamethasone injection (DRUG)
- Cosyntropin Injectable Product (DRUG)
- Recombinant Human Luteinizing Hormone (also known as luveris) (DRUG)
- Hydrocortisone Injection (also known as solu-cortef) (DRUG)
- Gonadorelin (also known as Lutrepulse) (DRUG)
- Corticorelin (also known as Acthrel) (DRUG)
- Placebo oral tablet (DRUG)
- Saline Solution (DRUG)
- Saline solution for injection (DRUG)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Los Angeles Biomedical Research Institute — Torrance, California
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Sleep Restriction
- Hormonal Mechanisms of Sleep Restriction - Axis Study — Torrance, California
Explore by condition: All Sleep Restriction clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.