Safety and Preliminary Efficacy of OBT076 in Recurrent/Metastatic CD205+ Solid Tumors (NCT04064359)
A Phase I, Open-label, Dose Finding Study to Assess the Safety, Tolerability, PK, and Preliminary Efficacy of OBT076, a CD205-directed ADC, in Recurrent and/or Metastatic CD205+ Solid Tumors
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to evaluate OBT076, which is a drug that combines an antibody with an anti-cancer drug. This class of drugs are called Antibody-Drug Conjugates (ADC). Antibodies are normally produced in the human body by the immune system to fight infections but can be designed to target cancer cells and deliver an anti-cancer drug. OBT076 is composed of an antibody that targets the CD205 protein on cancer cells and delivers an anti-cancer drug which can kill them. OBT076 is an "Investigational Drug", which means that it is still being studied and has not yet been approved by the US Food and Drug Administration (FDA), the European Medicines Agency (EMA) or any other regulatory authorities to be prescribed by doctors for the treatment of metastatic or recurrent solid tumors. The use of OBT076 in this study is investigational. This is a Phase I research study designed to look at several dose levels of the study drug to find the highest dose level that is safe and well-tolerated (does not cause unacceptable side effects), and to examine the effects of the study drug in a small group of research participants. The study will also look at the effectiveness of OBT076 as an anti-cancer therapy. Once the optimal dose is determined and safety is assessed, additional research participants will be treated at the optimal dose level to further evaluate safety and effectiveness.
Who can join: Review the eligibility criteria below.
Location: Mayo Clinic — Phoenix, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (27 Sites)
Showing the first 25 of 27 sites.
- Mayo Clinic — Phoenix, Arizona
- Cedars-Sinai — Los Angeles, California
- UCLA — Santa Monica, California
- Moffitt Cancer Center — Tampa, Florida
- The State University of Iowa — Iowa City, Iowa
- St. Elizabeth Healthcare — Edgewood, Kentucky
- University of Mississippi Medical Center — Jackson, Mississippi
- Quantum Santa Fe — Santa Fe, New Mexico
- Columbia University Medical Center — New York, New York
- University of Pittsburgh — Pittsburgh, Pennsylvania
- Institut Jules Bordet — Brussels,
- AZ Groeninge — Kortrijk,
- Institut Paoli Calmettes — Marseille,
- GHP Saint-Joseph — Paris,
- Hopital Saint Antoine — Paris,
- Hopital Saint Louis — Paris,
- Centre Eugène Marquis — Rennes,
- ICANS - Institut de cancérologie Strasbourg — Strasbourg,
- Institut Gustave Roussy - IGR — Villejuif,
- University General Hospital Attikon — Chaïdári, Athens
- Metropolitan Hospital — Athens,
- Sotiria General Hospital — Athens,
- University General Hospital of Heraklion — Heraklion,
- EuroMedica — Thessaloniki,
- START Barcelona HM Nou Delfos — Barcelona,
📞 Contact the Study Coordinator
Phone: +44 (0)1235 861770
Email: OBT076-001@oxfordbiotherapeutics.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.