🏛️ Verified NIH Record • Updated 2025-08-11

IMGN632 as Monotherapy or With Venetoclax and/or Azacitidine for Participants With CD123-Positive Acute Myeloid Leukemia (NCT04086264)

A Phase 1b/2 Study of IMGN632 as Monotherapy or Combination With Venetoclax and/or Azacitidine for Participants With CD123-Positive Acute Myeloid Leukemia

🔵 Active, Not Recruiting Phase1 / Phase2 💊 Investigational Drug / Biologic Sponsor: AbbVie

🩺 Plain-English Summary (8th-Grade Level)

This is an open-label, multicenter, Phase 1b/2 study to determine the safety and tolerability of IMGN632 and assess the antileukemia activity of IMGN632 when administered in combination with azacitidine and/or venetoclax in participants with relapsed and frontline CD123-positive AML.

Who can join: Review the eligibility criteria below.

Location: City of Hope National Medical Center /ID# 269273 — Duarte, California

Age range: 18 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (29 Sites)

Showing the first 25 of 29 sites.

  • City of Hope National Medical Center /ID# 269273 — Duarte, California
  • University Of California Irvine Medical Center /ID# 269275 — Orange, California
  • Moffitt Cancer Center /ID# 269269 — Tampa, Florida
  • Northwestern University- Robert H. Lurie Comprehensive Cancer Center /ID# 269642 — Chicago, Illinois
  • Dana-Farber Cancer Institute /ID# 269267 — Boston, Massachusetts
  • University of Michigan /ID# 269079 — Ann Arbor, Michigan
  • Mayo Clinic Hospital Rochester /ID# 269643 — Rochester, Minnesota
  • Roswell Park Cancer Institute /ID# 269266 — Buffalo, New York
  • New York Presbyterian Hospital Weill Cornell Medical Center /ID# 269271 — New York, New York
  • Duke University Health System /ID# 269268 — Durham, North Carolina
  • Cleveland Clinic - Cleveland /ID# 269272 — Cleveland, Ohio
  • MD Anderson Houston /ID# 269265 — Houston, Texas
  • Fred Hutchinson Cancer Research Center /ID# 269270 — Seattle, Washington
  • Institut Paoli-Calmettes /ID# 269080 — Marseille, Bouches-du-Rhone
  • IUCT Oncopole /ID# 269284 — Toulouse, Occitanie
  • Hôpital Saint-Louis /ID# 269282 — Paris, Paris
  • Centre Antoine-Lacassagne /ID# 269285 — Nice, Provence-Alpes-Côte d'Azur Region
  • Hospices Civils de Lyon - Centre Hospitalier Lyon-Sud /ID# 269286 — Pierre-Bénite, Rhone
  • Centre Hospitalier de Versailles André Mignot /ID# 269287 — Le Chesnay,
  • Universitaetsklinikum Ulm /ID# 269686 — Ulm, Baden-Wurttemberg
  • Universitaetsklinikum Muenster /ID# 269688 — Münster, North Rhine-Westphalia
  • Universitaetsklinikum Leipzig /ID# 269682 — Leipzig, Saxony
  • IRCCS AOU di Bologna Policlinico Sant Orsola Malpighi /ID# 269281 — Bologna, Bologna
  • Istituto Europeo Di Oncologia /ID# 269646 — Milan, Milano
  • Azienda Ospedaliero Universitaria Maggiore Della Carità /ID# 269280 — Novara, Novara

📞 Contact the Study Coordinator

Phone: (800) 826-4673

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗