IMGN632 as Monotherapy or With Venetoclax and/or Azacitidine for Participants With CD123-Positive Acute Myeloid Leukemia (NCT04086264)
A Phase 1b/2 Study of IMGN632 as Monotherapy or Combination With Venetoclax and/or Azacitidine for Participants With CD123-Positive Acute Myeloid Leukemia
🩺 Plain-English Summary (8th-Grade Level)
This is an open-label, multicenter, Phase 1b/2 study to determine the safety and tolerability of IMGN632 and assess the antileukemia activity of IMGN632 when administered in combination with azacitidine and/or venetoclax in participants with relapsed and frontline CD123-positive AML.
Who can join: Review the eligibility criteria below.
Location: City of Hope National Medical Center /ID# 269273 — Duarte, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (29 Sites)
Showing the first 25 of 29 sites.
- City of Hope National Medical Center /ID# 269273 — Duarte, California
- University Of California Irvine Medical Center /ID# 269275 — Orange, California
- Moffitt Cancer Center /ID# 269269 — Tampa, Florida
- Northwestern University- Robert H. Lurie Comprehensive Cancer Center /ID# 269642 — Chicago, Illinois
- Dana-Farber Cancer Institute /ID# 269267 — Boston, Massachusetts
- University of Michigan /ID# 269079 — Ann Arbor, Michigan
- Mayo Clinic Hospital Rochester /ID# 269643 — Rochester, Minnesota
- Roswell Park Cancer Institute /ID# 269266 — Buffalo, New York
- New York Presbyterian Hospital Weill Cornell Medical Center /ID# 269271 — New York, New York
- Duke University Health System /ID# 269268 — Durham, North Carolina
- Cleveland Clinic - Cleveland /ID# 269272 — Cleveland, Ohio
- MD Anderson Houston /ID# 269265 — Houston, Texas
- Fred Hutchinson Cancer Research Center /ID# 269270 — Seattle, Washington
- Institut Paoli-Calmettes /ID# 269080 — Marseille, Bouches-du-Rhone
- IUCT Oncopole /ID# 269284 — Toulouse, Occitanie
- Hôpital Saint-Louis /ID# 269282 — Paris, Paris
- Centre Antoine-Lacassagne /ID# 269285 — Nice, Provence-Alpes-Côte d'Azur Region
- Hospices Civils de Lyon - Centre Hospitalier Lyon-Sud /ID# 269286 — Pierre-Bénite, Rhone
- Centre Hospitalier de Versailles André Mignot /ID# 269287 — Le Chesnay,
- Universitaetsklinikum Ulm /ID# 269686 — Ulm, Baden-Wurttemberg
- Universitaetsklinikum Muenster /ID# 269688 — Münster, North Rhine-Westphalia
- Universitaetsklinikum Leipzig /ID# 269682 — Leipzig, Saxony
- IRCCS AOU di Bologna Policlinico Sant Orsola Malpighi /ID# 269281 — Bologna, Bologna
- Istituto Europeo Di Oncologia /ID# 269646 — Milan, Milano
- Azienda Ospedaliero Universitaria Maggiore Della Carità /ID# 269280 — Novara, Novara
📞 Contact the Study Coordinator
Phone: (800) 826-4673
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.