🏛️ Verified NIH Record • Updated 2026-08-27

A Study of Subcutaneous Daratumumab Regimens in Combination With Bispecific T Cell Redirection Antibodies for the Treatment of Participants With Multiple Myeloma (NCT04108195)

A Phase 1b Study of Subcutaneous Daratumumab Regimens in Combination With Bispecific T Cell Redirection Antibodies for the Treatment of Subjects With Multiple Myeloma

🔵 Active, Not Recruiting Phase1 💊 Investigational Drug / Biologic Sponsor: Janssen Research & Development, LLC

🩺 Plain-English Summary (8th-Grade Level)

The purpose of this study is to identify recommended Phase 2 doses (RP2Ds) for each treatment combination (between daratumumab plus talquetamab and teclistamab plus daratumumab with or without pomalidomide) and to characterize the safety of each RP2D for selected treatment combinations.

Who can join: Review the eligibility criteria below.

Location: City of Hope National Medical Center — Duarte, California

Age range: 18 Years

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (24 Sites)

  • City of Hope National Medical Center — Duarte, California
  • City of Hope Orange County Lennar Foundation Cancer Center — Irvine, California
  • University of California San Francisco — San Francisco, California
  • The Blavatnik Family Chelsea Medical Center at Mount Sinai — New York, New York
  • Mount Sinai Medical Center — New York, New York
  • Levine Cancer Institute — Charlotte, North Carolina
  • Wake Forest Baptist Medical Center — Winston-Salem, North Carolina
  • University of Pennsylvania — Philadelphia, Pennsylvania
  • Vanderbilt Ingram Cancer Center — Nashville, Tennessee
  • Medical College Of Wisconsin — Milwaukee, Wisconsin
  • Arthur J E Child Comprehensive Cancer Centre — Calgary, Alberta
  • University Health Network UHN Princess Margaret Cancer Centre — Toronto, Ontario
  • Universitatsklinikum Freiburg — Freiburg im Breisgau,
  • Universitaetsklinikum Hamburg Eppendorf — Hamburg,
  • Universitaetsklinikum Heidelberg — Heidelberg,
  • Universitatsklinikum Wurzburg — Würzburg,
  • VU Medisch Centrum — Amsterdam,
  • LUMC — Leiden,
  • Hosp Clinic de Barcelona — Barcelona,
  • Inst. Cat. Doncologia-H Duran I Reynals — Barcelona,
  • Germans Trias I Pujol — Barcelona,
  • Hosp Univ Fund Jimenez Diaz — Madrid,
  • Clinica Univ. de Navarra — Pamplona,
  • Hosp Clinico Univ de Salamanca — Salamanca,

📞 Contact the Study Coordinator

Phone: (800) 826-4673

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Multiple Myeloma clinical trials

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗