๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-02-23

Checkpoint Inhibition In Pediatric Hepatocellular Carcinoma (NCT04134559)

The Role of Checkpoint Inhibition in Relapsed/Refractory Pediatric Hepatocellular Carcinoma: Clinical Efficacy and Biologic Correlates - A Phase II Study

๐ŸŸข Recruiting Phase2 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Allison O'Neill, MD

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

This research study is studying an immunotherapy drug (pembrolizumab or KEYTRUDA) as a possible treatment for pediatric hepatocellular carcinoma or hepatocellular neoplasm not otherwise specified (HCN NOS).

Who can join: Review the eligibility criteria below.

Location: University of California San Francisco โ€” San Francisco, California

Age range: 0 Years to 30 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (5 Sites)

  • University of California San Francisco โ€” San Francisco, California
  • Children's Hospital Boston โ€” Boston, Massachusetts
  • Dana Farber Cancer Institute โ€” Boston, Massachusetts
  • Cincinnati Children's Medical Center โ€” Cincinnati, Ohio
  • Baylor College of Medicine โ€” Houston, Texas

๐Ÿ“ž Contact the Study Coordinator

Phone: (415) 476-3831

Email: arun.rangaswami@ucsf.edu

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—