fMRI in Postural Tachycardia Syndrome (NCT04137757)
Neural Correlates of Cognitive Dysfunction in Postural Tachycardia Syndrome
🩺 Plain-English Summary (8th-Grade Level)
Postural tachycardia syndrome (POTS) is one of the most common forms of chronic orthostatic intolerance in the United States. This is a disabling disorder characterized by an excessive increase in heart rate upon standing that is accompanied by symptoms such as dizziness and fatigue. One of the most under appreciated and bothersome symptoms of POTS is impaired cognition or "brain fog," which occurs to a level that interferes with daily activities such as work and education. Despite this high impact, the reasons why POTS patients have problems with cognition are not well understood. This project will test the overall hypothesis that "brain fog" in POTS is related to increased activation of cognitive brain regions during mental tasks when compared with healthy subjects, and that this activation is exacerbated by in the presence of orthostatic stress.
Who can join: Review the eligibility criteria below.
Location: Penn State Milton S. Hershey Medical Center — Hershey, Pennsylvania
Age range: 18 Years to 60 Years
🧪 Interventions in This Study
- Lower Body Negative Pressure (OTHER)
- Sham Pressure (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Penn State Milton S. Hershey Medical Center — Hershey, Pennsylvania
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Postural Tachycardia Syndrome
- Acute Salt Handling in Orthostatic Intolerance — Nashville, Tennessee
- Phenotyping Mitochondrial and Immune Dysfunction in POTS With Targeted Clinical Intervention. — La Jolla, California
- Sleep Actigraphy in Postural Tachycardia Syndrome (POTS) — Nashville, Tennessee
- Vagal Stimulation in POTS — Nashville, Tennessee
- Autonomic Determinants of POTS - Pilot 2 — Nashville, Tennessee
Explore by condition: All Postural Tachycardia Syndrome clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.