🏛️ Verified NIH Record • Updated 2022-10-26
NYX-458 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Parkinson's Disease or Lewy Body Dementia (Cognition, Memory, Attention, Thinking) (NCT04148391)
A Study to Evaluate NYX-458 in Subjects With Mild Cognitive Impairment or Mild Dementia Associated With Parkinson's Disease or Prodromal or Manifest Lewy Body Dementia
🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: Aptinyx
🩺 Plain-English Summary (8th-Grade Level)
A Study to Evaluate NYX-458 in Subjects With Mild Cognitive Impairment or Mild Dementia Associated With Parkinson's Disease or Prodromal or Manifest Lewy Body Dementia
Who can join: Review the eligibility criteria below.
Location: Aptinyx Clinical Site — Scottsdale, Arizona
Age range: 50 Years to 80 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (26 Sites)
Showing the first 25 of 26 sites.
- Aptinyx Clinical Site — Scottsdale, Arizona
- Aptinyx Clinical Site — Fresno, California
- Aptinyx Clinical Site — Simi Valley, California
- Aptinyx Clinical Site — Boca Raton, Florida
- Aptinyx Clinical Site — Bradenton, Florida
- Aptinyx Clinical Site — Miami, Florida
- Aptinyx Clinical Site — Miami, Florida
- Aptinyx Clinical Site — Miami, Florida
- Aptinyx Clinical Site — Miami, Florida
- Aptinyx Clinical Site — Miami Lakes, Florida
- Aptinyx Clinical Site — Orlando, Florida
- Aptinyx Clinical Site — Port Charlotte, Florida
- Aptinyx Clinical Site — Port Orange, Florida
- Aptinyx Clinical Site — Sunrise, Florida
- Aptinyx Clinical Site — Decatur, Georgia
- Aptinyx Clinical Site — Farmington Hills, Michigan
- Aptinyx Clinical Site — Golden Valley, Minnesota
- Aptinyx Clinical Site — Toms River, New Jersey
- Aptinyx Clinical Site — Poughkeepsie, New York
- Aptinyx Clinical Site — Asheville, North Carolina
- Aptinyx Clinical Site — Dayton, Ohio
- Aptinyx Clinical Site — Tulsa, Oklahoma
- Aptinyx Clinical Site — Round Rock, Texas
- Aptinyx Clinical Site — Sugar Land, Texas
- Aptinyx Clinical Site — Bellevue, Washington
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- Low Intensity Focused Ultrasound for Mild Cognitive Impairment and Mild Alzheimer's Disease — Los Angeles, California
Explore by condition: All Mild Cognitive Impairment clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.