HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy (NCT04153149)
HELIOS-B: A Phase 3, Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy (ATTR Amyloidosis With Cardiomyopathy)
🩺 Plain-English Summary (8th-Grade Level)
This study will evaluate the efficacy and safety of vutrisiran 25 mg administered subcutaneously (SC) once every 3 months (q3M) compared to placebo in participants with ATTR amyloidosis with cardiomyopathy.
Who can join: Review the eligibility criteria below.
Location: Clinical Trial Site — La Mesa, California
Age range: 18 Years to 85 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (119 Sites)
Showing the first 25 of 119 sites.
- Clinical Trial Site — La Mesa, California
- Clinical Trial Site — Los Angeles, California
- Clinical Trial Site — Stanford, California
- Clinical Trial Site — Washington D.C., District of Columbia
- Clinical Trial Site — Gainesville, Georgia
- Clinical Trial Site — Chicago, Illinois
- Clinical Trial Site — Evanston, Illinois
- Clinical Trial Site — Boston, Massachusetts
- Clinical Trial Site — Boston, Massachusetts
- Clinical Trial Site — Rochester, Minnesota
- Clinical Trial Site — Manhasset, New York
- Clinical Trial Site — New York, New York
- Clinical Trial Site — Durham, North Carolina
- Clinical Trial Site — Cleveland, Ohio
- Clinical Trial Site — Allentown, Pennsylvania
- Clinical Trial Site — Philadelphia, Pennsylvania
- Clinical Trial Site — Houston, Texas
- Clinical Trial Site — Buenos Aires, Ciudad Autónoma de BuenosAires
- Clinical Trial Site — Buenos Aires, Pilar
- Clinical Trial Site — Buenos Aires,
- Clinical Trial Site — Buenos Aires,
- Clinical Trial Site — Darlinghurst, New South Wales
- Clinical Trial Site — Northmead, New South Wales
- Clinical Trial Site — Woolloongabba, Queensland
- Clinical Trial Site — Adelaide, South Australia
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.