Study of Single Agent Belantamab Mafodotin Versus Pomalidomide Plus Low-dose Dexamethasone (Pom/Dex) in Participants With Relapsed/Refractory Multiple Myeloma (RRMM) (NCT04162210)
A Phase III, Open-Label, Randomized Study to Evaluate the Efficacy and Safety of Single Agent Belantamab Mafodotin Compared to Pomalidomide Plus Lowdose Dexamethasone (Pom/Dex) in Participants With Relapsed/Refractory Multiple Myeloma (RRMM) (DREAMM 3)
🩺 Plain-English Summary (8th-Grade Level)
This open-label, randomized study for evaluating the efficacy and safety of single agent belantamab mafodotin when compared to pom/dex in participants with RRMM. Participants will be randomized in a 2:1 ratio to receive either single agent belantamab mafodotin or pom/dex. Belantamab mafodotin will be administered on Day 1 (D1) at every 3 weeks (Q3W) schedule. Pomalidomide will be administered daily on Days 1 to 21 of each 28-day cycle, with dexamethasone administered once weekly (Days 1, 8, 15, and 22). Participants in both arms will be treated until disease progression, death, unacceptable toxicity, withdrawal of consent, and lost to follow-up or end of study, whichever comes first.
Who can join: Review the eligibility criteria below.
Location: GSK Investigational Site — Tucson, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (136 Sites)
Showing the first 25 of 136 sites.
- GSK Investigational Site — Tucson, Arizona
- GSK Investigational Site — Pueblo, Colorado
- GSK Investigational Site — Detroit, Michigan
- GSK Investigational Site — Omaha, Nebraska
- GSK Investigational Site — Clifton Park, New York
- GSK Investigational Site — Cincinnati, Ohio
- GSK Investigational Site — Corvallis, Oregon
- GSK Investigational Site — Eugene, Oregon
- GSK Investigational Site — Tyler, Texas
- GSK Investigational Site — Milwaukee, Wisconsin
- GSK Investigational Site — Gosford NSW, New South Wales
- GSK Investigational Site — Liverpool, New South Wales
- GSK Investigational Site — St Leonards, New South Wales
- GSK Investigational Site — Woodville, South Australia
- GSK Investigational Site — Hobart, Tasmania
- GSK Investigational Site — Clayton, Victoria
- GSK Investigational Site — Fitzroy, Victoria
- GSK Investigational Site — Geelong, Victoria
- GSK Investigational Site — Nedlands, Western Australia
- GSK Investigational Site — St Albans,
- GSK Investigational Site — Bruges,
- GSK Investigational Site — Brussels,
- GSK Investigational Site — Brussels,
- GSK Investigational Site — Edegem,
- GSK Investigational Site — Kortrijk,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- Multiple Myeloma Outcomes Based on Maintenance Therapy Post Autologous Stem Cell Transplant — Tampa, Florida
- MagnetisMM-3: Study Of Elranatamab (PF-06863135) Monotherapy in Participants With Multiple Myeloma Who Are Refractory to at Least One PI, One IMiD and One Anti-CD38 mAb — Beverly Hills, California
- A Study of CLN-619 (Anti-MICA/MICB Antibody) in Patients With Relapsed and Refractory Multiple Myeloma — Phoenix, Arizona
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Explore by condition: All Multiple Myeloma clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.