Trial-Ready Cohort-Down Syndrome (TRC-DS) (NCT04165109)
Alzheimer's Clinical Trial Consortium for Down Syndrome (ACTC-DS) Trial-Ready Cohort - Down Syndrome (TRC-DS)
🩺 Plain-English Summary (8th-Grade Level)
The purpose of the Trial-Ready Cohort - Down Syndrome (TRC-DS) is to enroll 120 healthy adults with Down syndrome (DS), between the ages of 25-55, into a trial ready cohort (TRC), and up to 550 participants in total including co-enrolled in the Alzheimer Biomarkers Consortium - Down Syndrome (ABC-DS) study. Participants enrolled in the TRC-DS will undergo longitudinal cognitive and clinical assessment, genetic and biomarker testing, as well as imaging and biospecimen collection. Using these outcome measures, researchers will analyze the relationships between cognitive measures and biomarkers of Alzheimer's disease (AD) to identify endpoints for AD clinical trials in DS that best reflect disease progression. To learn more about the study and participating sites, visit our study website at: https://www.trcds.org/. TRC-DS is collaborating with the Alzheimer's Disease Biomarker Consortium-Down Syndrome (ABC-DS) to allow study participants to be concurrently enrolled in both ABC-DS and TRC-DS, referred to as "co-enrollment". ABC-DS is a longitudinal, observational research study that is overseen at University of Pittsburgh Coordinating Center. ABC-DS participants who express interest in potentially joining a clinical trial in the future and who meet TRC-DS eligibility criteria, may choose to co-enroll in TRC-DS at an ABC-DS Site. Co-enrolled participants will adhere to the ABC-DS protocol and schedule of activities, but agree to share their data with the TRC-DS team and to receive invitations for future participation in clinical trials. Fore more information on ABC-DS please visit https://www.nia.nih.gov/research/abc-ds or http://abcds.pitt.edu/.
Who can join: Review the eligibility criteria below.
Location: Barrow Neurological Institute — Phoenix, Arizona
Age range: 25 Years to 55 Years
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (22 Sites)
- Barrow Neurological Institute — Phoenix, Arizona
- University of California, Irvine School of Medicine, Co-Enrolling through ABC-DS Only — Orange, California
- Linda Crnic Institute for Down Syndrome, University of Colorado — Aurora, Colorado
- Advocate Medical Group Adult Down Syndrome Center — Park Ridge, Illinois
- Indiana University — Indianapolis, Indiana
- University of Kansas Medical Center — Kansas City, Kansas
- University of Kentucky, Co-Enrolling through ABC-DS Only — Lexington, Kentucky
- Massachusetts General Hospital, Co-Enrolling through ABC-DS Only — Boston, Massachusetts
- Washington University, St. Louis — St Louis, Missouri
- Cleveland Clinic, Lou Ruvo Center for Brain Health, Las Vegas — Las Vegas, Nevada
- New York State Institute for Basic Research in Developmental Disabilities (SIBRDD), Co-Enrolling through ABC-DS Only — Staten Island, New York
- Case Western Reserve University — Beachwood, Ohio
- University of Cincinnati — Cincinnati, Ohio
- Oregon Health & Science University — Portland, Oregon
- University of Pittsburgh, Co-Enrolling through ABC-DS Only — Pittsburgh, Pennsylvania
- Vanderbilt University Medical Center Center for Cognitive Medicine — Nashville, Tennessee
- University of Texas Health San Antonio, Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases — San Antonio, Texas
- University of Wisconsin - Madison, Waisman Center, Co-Enrolling through ABC-DS Only — Madison, Wisconsin
- Institut Jerome Lejeune — Paris, France
- Institute of Memory & Cognition, Tallaght University Hospital — Dublin, Ireland
- Sant Pau Biomedical Research Institute (IIB Sant Pau) — Barcelona,
- University of Cambridge, Co-Enrolling through ABC-DS Only — Cambridge,
📞 Contact the Study Coordinator
Phone: (213) 821-0569
Email: DS-participate@usc.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Down Syndrome
- Evaluating Treatment of ADHD in Children With Down Syndrome — Sacramento, California
- Effects of Hypoglossal Nerve Stimulation on Cognition and Language in Down Syndrome and Obstructive Sleep Apnea — Atlanta, Georgia
- Using Personal Mobile Technology to Identify Obstructive Sleep Apnea in Children With Down Syndrome (UPLOAD) — Ottawa, Ontario
- Executive Function Play Opportunities for Children With Down Syndrome — Fort Collins, Colorado
- Escalating Doses of Memantine in Down Syndrome (MEDS-123) — Cleveland, Ohio
- Natural History of Dysregulation and Aging of the Immune System in People With Trisomy 21 With and Without Thymectomy — Bethesda, Maryland
Explore by condition: All Down Syndrome clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.