Sotorasib Activity in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation (CodeBreak 101) (NCT04185883)

🧪 Interventions in This Study

• Sotorasib (DRUG)
• Trametinib (DRUG)
• RMC-4630 (DRUG)
• Afatinib (DRUG)
• Pembrolizumab (DRUG)
• Panitumumab (DRUG)
• Carboplatin, pemetrexed, docetaxel, paclitaxel (DRUG)
• Atezolizumab (DRUG)
• Palbociclib (DRUG)
• MVASI® (bevacizumab-awwb) (DRUG)
• TNO155 (DRUG)
• IV Chemotherapy (Regimen 1) (DRUG)
• IV Chemotherapy (Regimen 2) (DRUG)
• BI 1701963 (DRUG)
• AMG 404 (DRUG)
• Everolimus (DRUG)

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (90 Sites)

Showing the first 25 of 90 sites.

• Arizona Oncology Associates Professional Corporation — Tucson, Arizona
• City of Hope National Medical Center — Duarte, California
• University of California San Diego Moores Cancer Center — La Jolla, California
• Loma Linda University Cancer Center — Loma Linda, California
• University of Southern California, Norris Comprehensive Cancer Center — Los Angeles, California
• University of California Davis Medical Center — Sacramento, California
• University of California San Francisco Mission Bay Campus — San Francisco, California
• University of California Los Angeles — Santa Monica, California
• Rocky Mountain Cancer Centers Denver Midtown — Denver, Colorado
• Sarah Cannon Research Institute — Denver, Colorado
• Yale New Haven Hospital — New Haven, Connecticut
• Norwalk Hospital — Norwalk, Connecticut
• Memorial Cancer Institute — Pembroke Pines, Florida
• Moffitt Cancer Center — Tampa, Florida
• Emory University — Atlanta, Georgia
• Northwestern University — Chicago, Illinois
• University of Chicago — Chicago, Illinois
• Indiana University — Indianapolis, Indiana
• University of Iowa Hospitals and Clinics — Iowa City, Iowa
• Johns Hopkins University — Baltimore, Maryland
• University of Michigan — Ann Arbor, Michigan
• Henry Ford Cancer Detroit (Brigitte Harris Cancer Pavilion) — Detroit, Michigan
• Washington University — St Louis, Missouri
• Roswell Park Cancer Institute — Buffalo, New York
• Icahn School of Medicine at Mount Sinai — New York, New York

💰 Cost, Insurance & Patient Rights

• 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
• Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
• Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

More studies in Advanced Solid Tumors

• A Study of FF-10850 Topotecan Liposome Injection in Advanced Solid Tumors Including Merkel Cell Carcinoma — Scottsdale, Arizona
• A Study of MRG002 in Patients with HER2-Positive Advanced Solid Tumors and Locally Advanced or Metastatic Gastric/Gastroesophageal Junction (GEJ) Cancer — Orange, California
• QTX3544 in Patients With Advanced Solid Tumors With KRAS G12V Mutations — Denver, Colorado
• A First-in-human Study to Learn How Safe the Study Drug BAY2965501 is, Find the Best Dose (Single Drug & Combination), How it Affects the Body, What Maximum Amount Can be Given, How it Moves Into, Through and Out of the Body, How it Acts on Different Tumors in Participants With Advanced Solid Tumors — Denver, Colorado
• A Phase 1 Dose-escalation Study of FF-10832 for Treatment of Solid Tumors Including Biliary Tract Cancer — Scottsdale, Arizona
• A Phase 1 Study of ATV-1601 in Patients With Advanced Cancer That Have AKT1 E17K Mutations — Los Angeles, California

Explore by condition: All Advanced Solid Tumors clinical trials

💡 How to Participate

1. Check the checklist above to see if you may qualify.
2. Review the official NIH record below to find the coordinating site.
3. Ask about the visit schedule, what is covered at no cost, and any travel support.
4. Confirm with your own doctor before making a decision.