Who is eligible for clinical trial NCT04214288?

Participants must meet protocol criteria for Advanced ER-Positive HER2-Negative Breast Cancer. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT04214288 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-08-24

A Study to Investigate Efficacy and Safety With Oral AZD9833 Compared With Intramuscular Fulvestrant in Post-menopausal Women at Least 18 Years of Age With Advanced ER-positive HER2 Negative Breast Cancer (NCT04214288)

SERENA-2: A Randomised, Open-Label, Parallel-Group, Multicentre Phase 2 Study Comparing the Efficacy and Safety of Oral AZD9833 Versus Fulvestrant in Women With Advanced ER-Positive HER2-Negative Breast Cancer

🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: AstraZeneca

🩺 Plain-English Summary (8th-Grade Level)

This study is randomized, open-label, parallel-group, multicentre Phase 2 study aimed to compare the efficacy and safety of oral AZD9833 versus intramuscular (IM) fulvestrant in women with advanced breast cancer.

Who can join: Review the eligibility criteria below.

Location: Research Site — Birmingham, Alabama

Age range: 18 Years to 130 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (85 Sites)

Showing the first 25 of 85 sites.

Research Site — Birmingham, Alabama
Research Site — Long Beach, California
Research Site — Fort Myers, Florida
Research Site — St. Petersburg, Florida
Research Site — Lincoln, Nebraska
Research Site — Canton, Ohio
Research Site — Chattanooga, Tennessee
Research Site — Nashville, Tennessee
Research Site — Eagle River, Wisconsin
Research Site — Brasschaat,
Research Site — Charleroi,
Research Site — Ghent,
Research Site — Haine-Saint-Paul,
Research Site — Leuven,
Research Site — Libramont-Chevigny,
Research Site — Namur,
Research Site — Greenfield Park, Quebec
Research Site — Montreal, Quebec
Research Site — Montreal, Quebec
Research Site — Paris,
Research Site — Vandœuvre-lès-Nancy,
Research Site — Batumi,
Research Site — Tbilisi,
Research Site — Tbilisi,
Research Site — Tbilisi,

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Advanced ER-Positive HER2-Negative Breast Cancer clinical trials

💡 How to Participate

Check the checklist above to see if you may qualify.
Review the official NIH record below to find the coordinating site.
Ask about the visit schedule, what is covered at no cost, and any travel support.
Confirm with your own doctor before making a decision.

🏛️ View Official NIH Record ↗