IMPact on Revascularization Outcomes of IVUS Guided Treatment of Complex Lesions and Economic Impact (NCT04221815)
IMPact on Revascularization Outcomes of intraVascular Ultrasound Guided Treatment of Complex Lesions and Economic Impact (IMPROVE)
🩺 Plain-English Summary (8th-Grade Level)
Intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) has been shown in clinical trials, registries, and meta-analyses to reduce recurrent events after PCI. This is accomplished by improving the angiographic result with lesion and vessel assessment to guide stent selection and implantation and intravascular imaging following stent implantation to ensure an adequate treatment endpoint has been achieved. Despite extensive literature supporting the use of IVUS in PCI, utilization remains low in the United States. An increasing number of high-risk or complex lesions are being treated with PCI and we hypothesize that the impact of IVUS in these complex lesions will be of increased importance in reducing clinical adverse events while remaining cost effective.
Who can join: Review the eligibility criteria below.
Location: Northwest Medical Center — Tucson, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (61 Sites)
Showing the first 25 of 61 sites.
- Northwest Medical Center — Tucson, Arizona
- Central Arkansas Veterans Healthcare System — Little Rock, Arkansas
- University of California San Deigo — La Jolla, California
- San Francisco VA Health Care System — San Francisco, California
- San Antonio Regional Hospital — Upland, California
- Medstar Washington Hospital Center — Washington D.C., District of Columbia
- Manatee Memorial Hospital — Bradenton, Florida
- AdventHealth Orlando — Orlando, Florida
- Ascension Sacred Heart — Pensacola, Florida
- AdventHealth Sebring — Sebring, Florida
- Tampa Cardiovascular/St. Joseph's Hospital — Tampa, Florida
- Emory — Atlanta, Georgia
- Atlanta VA Medical Center — Decatur, Georgia
- Northeast Georgia Medical Center — Gainesville, Georgia
- Rush University Medial Center — Chicago, Illinois
- Riverside Medical Center — Kankakee, Illinois
- Carle Foundation Hospital — Urbana, Illinois
- MercyOne Iowa Heart Center — Des Moines, Iowa
- MedStar Union Memorial Hospital — Baltimore, Maryland
- MedStar Southern Maryland Hospital Center — Clinton, Maryland
- Massachusetts General Hospital — Boston, Massachusetts
- Brigham and Women's Hospital — Boston, Massachusetts
- Baystate Medical Center — Springfield, Massachusetts
- Ascension St. John — Dearborn, Michigan
- St. Luke's Hospital of Duluth — Duluth, Minnesota
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.