🏛️ Verified NIH Record • Updated 2026-06-16

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab + Lenalidomide (+Len), and the Safety, Tolerability, and Pharmacokinetics of SC Versus IV Mosunetuzumab + Len in Participants With Follicular Lymphoma (NCT04246086)

A Phase Ib/II, Open-Label, Multicenter Study With a Non-Randomized Stage Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab Plus Lenalidomide (+Len), and a Randomized Stage Evaluating the Safety, Tolerability, and Pharmacokinetics of SC Versus IV Mosunetuzumab + Len in Patients With Follicular Lymphoma

🔵 Active, Not Recruiting Phase1 / Phase2 💊 Investigational Drug / Biologic Sponsor: Hoffmann-La Roche

🩺 Plain-English Summary (8th-Grade Level)

This study will evaluate the safety, efficacy, pharmacokinetics, and immunogenicity of mosunetuzumab (Mosun) + lenalidomide (Len) (Mosun + Len) in participants with follicular lymphoma (FL). This study will also compare the pharmacokinetics, pharmacodynamics, safety, efficacy, and immunogenicity of IV mosunetuzumab + len vs subcutaneous (SC) mosunetuzumab + len.

Who can join: Review the eligibility criteria below.

Location: City of Hope National Medical Center — Duarte, California

Age range: 18 Years

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (26 Sites)

Showing the first 25 of 26 sites.

  • City of Hope National Medical Center — Duarte, California
  • University of Miami Miller School of Medicine — Miami, Florida
  • Norton Cancer Institute - St. Matthews — Louisville, Kentucky
  • Mary Bird Perkins Cancer Ctr — Baton Rouge, Louisiana
  • University of Michigan Comprehensive Cancer Center — Ann Arbor, Michigan
  • Duke University Medical Center — Durham, North Carolina
  • Fairview Hospital — Cleveland, Ohio
  • Cleveland Clinic — Cleveland, Ohio
  • Hillcrest Hospital — Mayfield Heights, Ohio
  • Rhode Island Hematology/Oncology Program — Woonsocket, Rhode Island
  • Tennessee Oncology;Chattanooga Oncology & Hematology Associates — Chattanooga, Tennessee
  • Tennessee Oncology PLLC - Franklin — Franklin, Tennessee
  • Swedish Medical Center — Seattle, Washington
  • The First Hospital of Jilin University — Changchun,
  • West China Hospital, Sichuan University — Chengdu,
  • Fudan University Shanghai Cancer Center — Shanghai,
  • Tianjin Medical University Cancer Institute & Hospital — Tianjing,
  • The First Affiliated Hospital of Xiamen University — Xiamen,
  • Centre Hospitalier Lyon Sud — Pierre-Bénite,
  • CHU Rennes - Hopital Pontchaillou — Rennes,
  • Hospital Universitario Fundacion Jimenez Diaz. — Madrid,
  • Hospital Universitario Virgen de la Victoria — Málaga,
  • University College London Hospitals NHS Foundation Trust - University College Hospital — London,
  • The Christie NHS Foundation Trust — Manchester,
  • Freeman Hospital — Newcastle upon Tyne,

📞 Contact the Study Coordinator

Phone: (800) 826-4673

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗