A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab + Lenalidomide (+Len), and the Safety, Tolerability, and Pharmacokinetics of SC Versus IV Mosunetuzumab + Len in Participants With Follicular Lymphoma (NCT04246086)
A Phase Ib/II, Open-Label, Multicenter Study With a Non-Randomized Stage Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab Plus Lenalidomide (+Len), and a Randomized Stage Evaluating the Safety, Tolerability, and Pharmacokinetics of SC Versus IV Mosunetuzumab + Len in Patients With Follicular Lymphoma
🩺 Plain-English Summary (8th-Grade Level)
This study will evaluate the safety, efficacy, pharmacokinetics, and immunogenicity of mosunetuzumab (Mosun) + lenalidomide (Len) (Mosun + Len) in participants with follicular lymphoma (FL). This study will also compare the pharmacokinetics, pharmacodynamics, safety, efficacy, and immunogenicity of IV mosunetuzumab + len vs subcutaneous (SC) mosunetuzumab + len.
Who can join: Review the eligibility criteria below.
Location: City of Hope National Medical Center — Duarte, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (26 Sites)
Showing the first 25 of 26 sites.
- City of Hope National Medical Center — Duarte, California
- University of Miami Miller School of Medicine — Miami, Florida
- Norton Cancer Institute - St. Matthews — Louisville, Kentucky
- Mary Bird Perkins Cancer Ctr — Baton Rouge, Louisiana
- University of Michigan Comprehensive Cancer Center — Ann Arbor, Michigan
- Duke University Medical Center — Durham, North Carolina
- Fairview Hospital — Cleveland, Ohio
- Cleveland Clinic — Cleveland, Ohio
- Hillcrest Hospital — Mayfield Heights, Ohio
- Rhode Island Hematology/Oncology Program — Woonsocket, Rhode Island
- Tennessee Oncology;Chattanooga Oncology & Hematology Associates — Chattanooga, Tennessee
- Tennessee Oncology PLLC - Franklin — Franklin, Tennessee
- Swedish Medical Center — Seattle, Washington
- The First Hospital of Jilin University — Changchun,
- West China Hospital, Sichuan University — Chengdu,
- Fudan University Shanghai Cancer Center — Shanghai,
- Tianjin Medical University Cancer Institute & Hospital — Tianjing,
- The First Affiliated Hospital of Xiamen University — Xiamen,
- Centre Hospitalier Lyon Sud — Pierre-Bénite,
- CHU Rennes - Hopital Pontchaillou — Rennes,
- Hospital Universitario Fundacion Jimenez Diaz. — Madrid,
- Hospital Universitario Virgen de la Victoria — Málaga,
- University College London Hospitals NHS Foundation Trust - University College Hospital — London,
- The Christie NHS Foundation Trust — Manchester,
- Freeman Hospital — Newcastle upon Tyne,
📞 Contact the Study Coordinator
Phone: (800) 826-4673
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Follicular Lymphoma
- A Feasibility Trial of Tazemetostat Plus CAR T Cell Therapy in B-cell Lymphomas — New York, New York
- Response-Adapted Therapy With Copanlisib and Rituximab in Untreated Follicular Lymphoma — Bethesda, Maryland
- Measuring Cell-Free DNA (cfDNA) Levels in People With Follicular Lymphoma — Basking Ridge, New Jersey
- Tazemetostat and Mosunetuzumab in Untreated Follicular Lymphoma — New York, New York
- Glofit and Obin in Follicular Lymphoma and Marginal Zone Lymphoma — Boston, Massachusetts
- A Phase 3 Study to Assess Efficacy and Safety of Tafasitamab Plus Lenalidomide and Rituximab Compared to Placebo Plus Lenalidomide and Rituximab in Patients With Relapsed/Refractory (R/R) Follicular Lymphoma or Marginal Zone Lymphoma. — Concord, California
Explore by condition: All Follicular Lymphoma clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.