🏛️ Verified NIH Record • Updated 2026-08-27
RETHINK REFLUX Registry (NCT04253392)
Research to Further Inform Thinking About the Role of LINX for Reflux Disease
🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research Sponsor: Ethicon Endo-Surgery
🩺 Plain-English Summary (8th-Grade Level)
The RETHINK REFLUX Registry is a post-market prospective, multi-center, observation, single arm, long-term safety surveillance registry of subjects implanted with the LINX device. The primary objective of the study is to confirm the long-term safety profile of the LINX device and procedure (implant/explant) up to 10 years post-implant.
Who can join: Review the eligibility criteria below.
Location: University of South Alabama — Mobile, Alabama
Age range: 21 Years to 99 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (28 Sites)
Showing the first 25 of 28 sites.
- University of South Alabama — Mobile, Alabama
- NW Allied Bariatric and Foregut Surgery — Tucson, Arizona
- Keck Hospital of USC — Los Angeles, California
- Institute of Esophageal and Reflux Surgery — Englewood, Colorado
- University of Southern Florida (Tampa General Hospital) — Tampa, Florida
- OSF Medical Group — Peoria, Illinois
- Saint Elizabeth Healthcare Edgewood — Edgewood, Kentucky
- Sparrow Hospital / Sparrow Medical Group — Lansing, Michigan
- East Carolina University / Vidant Medical Center — Greenville, North Carolina
- The Ohio State University — Columbus, Ohio
- Gen Surg Assoc / Fairfield Medical Center — Lancaster, Ohio
- Lehigh Valley Hospital - Cedar Crest — Allentown, Pennsylvania
- Minimal Access Surgery/Prisma Health - Upstate — Greenville, South Carolina
- Adv Surg Assoc / Self Regional Healthcare — Greenwood, South Carolina
- Lexington Surgery — West Columbia, South Carolina
- Panhandle Weight Loss Center — Amarillo, Texas
- Houston Methodist — Houston, Texas
- Bariatric Medical Institute of Texas — San Antonio, Texas
- Richmond Surg / Henrico Doctors' Hospital — Richmond, Virginia
- Swedish Medical Center — Seattle, Washington
- Fox Valley Surgical Associates — Appleton, Wisconsin
- MedUni Wien / Universitatsklinik fur Chirurgie — Vienna,
- Marien Hospital Herne — Herne,
- Univ of Milano / IRCCS Policlinico San Donato — San Donato Milanese,
- National University Hospital — Singapore,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Gastroesophageal Reflux
- Gracie Diet for Gastroesophageal Reflux Disease — Baltimore, Maryland
- Developing and Testing Mobile Health Question Prompt List in Gastroesophageal Reflux Disease — Stanford, California
- A Study of Breath Testing for Small Intestinal Bacterial Overgrowth — Jacksonville, Florida
- External UES Band (Shaker Pressure Band) and GERD — Milwaukee, Wisconsin
- Post-sleeve Gastrectomy Gastroesophageal Reflux Disease Prediction — Orlando, Florida
Explore by condition: All Gastroesophageal Reflux clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.