Phase 1 Study of Locoregional Injections of Ex Vivo Expanded Natural Killer Cells (NCT04254419)
Phase 1 Study of Locoregional Injections of Ex Vivo Expanded Natural Killer Cells in Children and Young Adults With Recurrent, Progressive, or Refractory Brain Tumors
๐ฉบ Plain-English Summary (8th-Grade Level)
Each patient will receive up to 12 cycles of TGFฮฒi NK cell infusions. Each cycle will be of 4 weeks duration. During the first 3 weeks, TGFฮฒi NK cells will be infused once weekly. The 4th week will be a rest week. TGFฮฒi NK cell infusions should be delivered at least 3 days apart (e.g., Friday of Week 1 and Monday of Week 2). Dose will be escalated in an inter-patient stepwise fashion consisting of 3 dose levels.
Who can join: Review the eligibility criteria below.
Location: Nationwide Children's Hospital โ Columbus, Ohio
Age range: 12 Months to 39 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (1 Sites)
- Nationwide Children's Hospital โ Columbus, Ohio
๐ Contact the Study Coordinator
Phone: (614) 722-5634
Email: Clelie.Peck@nationwidechildrens.org
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.