Perioperative Respiratory Care and Outcomes for Patients Undergoing High Risk Abdominal Surgery (NCT04256798)
PErioperative Respiratory Care and Outcomes for patieNts Undergoing hIgh Risk abdomiNal Surgery: A 2x2 Factorial, International Pragmatic Randomised Controlled Trial Across Low and Middle-income Countries
🩺 Plain-English Summary (8th-Grade Level)
PENGUIN is a pragmatic multi-center trial investigating the effects of pre-operative mouthwash and perioperative oxygen on the incidences of pneumonia and surgical site infection (SSI) following major abdominal surgery. Patients will be recruited from low and middle income countries and randomly assigned to a trial treatment arms: a) pre-operative chlorhexidine mouthwash and 80-100% FiO2; b) no pre-operative mouthwash and 80-100% fraction of inspired oxygen (FiO2); c) pre-operative chlorhexidine mouthwash and 21- 30% FiO2; or d) no pre-operative mouthwash and 21-30% FiO2.
Who can join: Review the eligibility criteria below.
Location: Hospital das Clinicas da Faculdade de Medicina de Botucatu - UNESP — Botucatu, São Paulo
Age range: 10 Years to 100 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (37 Sites)
Showing the first 25 of 37 sites.
- Hospital das Clinicas da Faculdade de Medicina de Botucatu - UNESP — Botucatu, São Paulo
- Hospital de Clinicas de Porto Alegre — Porto Alegre,
- Hospital Nossa Senhora da Conceicao — Porto Alegre,
- Hospital Universitario Professor Edgar Santos/Bahia — Salvador,
- Hospital Sao Jose - Criciuma/SC — São José,
- Homi Bhabha Cancer Hospital & Research Centre — Visakhapatnam, Andhra Pradesh
- Sher - i - Kashmir Institute of Medical Sciences — Srinagar, Jammu and Kashmir
- Chinchpada Christian Hospital — Chinchpāda, Maharashtra
- Kasturba Medical College Hospital, Manipal — Madhava Nagar, Manipal, Karnataka
- Government Medical College, Patiala — Patiāla, Punjab
- All India Institute of Medical Sciences, Bhubaneswar — Bhubaneswar,
- Government Medial College & Hospital, Chandigarh — Chandigarh,
- All India Institute of Medical Sciences, Jodhpur — Jodhpur,
- Tata Medical Center — Kolkata,
- Christian Medical College (CMC) & Hospital, Ludhiana — Ludhiana,
- Madhepura Christian Hospital — Madhepura,
- Topiwala National Medical College and Bai Yamunabai Laxman Nair Charitable Hospital — Mumbai,
- Tata Memorial Hospital — Mumbai,
- Maulana Azad Medical College — New Delhi,
- All India Institute of Medical Sciences, Rishikesh — Rishikesh,
- Christian Medical College & Hospital Vellore — Vellore,
- Centro Médico Nacional de Occidente IMSS — Belisario Domínguez,
- Hospital Espanola Veracruz — Veracruz,
- University of Benin Teaching Hospital — Benin City,
- University Of Abuja Teaching Hospital — Gwagwalada,
📞 Contact the Study Coordinator
Phone: 01214159127
Email: penguin@trials.bham.ac.uk
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.