Study in Parkinson Disease of Exercise (NCT04284436)
Study in Parkinson Disease of Exercise Phase 3 Clinical Trial: SPARX3
🩺 Plain-English Summary (8th-Grade Level)
This study is a Phase 3 multi-site, randomized, evaluator-masked, study of endurance treadmill exercise on changes in the Movement Disorder Society-Unified Parkinson Disease Rating Scale (MDS-UPDRS) Part III score at 12 months among persons with early stage Parkinson disease. 370 participants will be randomly assigned to 2 groups: 1)60-65% HRmax or 2)80-85% HRmax 4 times per week. The primary objective is to test whether the progression of the signs of Parkinson's disease is attenuated at 12 months in among persons who have not initiated medication for Parkinson Disease (PD) when they perform high-intensity endurance treadmill exercise.
Who can join: Review the eligibility criteria below.
Location: University of Alabama at Birmingham — Birmingham, Alabama
Age range: 40 Years to 80 Years
🧪 Interventions in This Study
- Treadmill walking (BEHAVIORAL)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (25 Sites)
- University of Alabama at Birmingham — Birmingham, Alabama
- University of California, San Francisco — San Francisco, California
- University of Colorado, Denver — Aurora, Colorado
- University of Florida — Gainesville, Florida
- Morehouse School of Medicine — Atlanta, Georgia
- Emory University — Atlanta, Georgia
- Northwestern University — Chicago, Illinois
- Rush University Medical Center — Chicago, Illinois
- Iowa State University — Ames, Iowa
- Louisiana State University — Baton Rouge, Louisiana
- Boston University (Charles River Campus) — Boston, Massachusetts
- University of Michigan — Ann Arbor, Michigan
- University of Minnesota — Minneapolis, Minnesota
- Washington University St. Louis — St Louis, Missouri
- Columbia University Medical Center — New York, New York
- University of Cincinnati — Cincinnati, Ohio
- Cleveland Clinic — Cleveland, Ohio
- Ohio Health — Columbus, Ohio
- Kent State University — Kent, Ohio
- Oregon Health & Science University — Portland, Oregon
- University of Pennsylvania — Philadelphia, Pennsylvania
- University of Pittsburgh — Pittsburgh, Pennsylvania
- UT Health San Antonio — San Antonio, Texas
- University of Utah — Salt Lake City, Utah
- University of Alberta — Edmonton,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Parkinson Disease
- Remote Optimization, Adjustment and Measurement for Deep Brain Stimulation — Tucson, Arizona
- Parkinson's Disease Progression Study — Aurora, Colorado
- To Evaluate the Efficacy of CVN424 in Parkinson's Disease Participants With Motor Complications — Birmingham, Alabama
- Mobile Parkinson Observatory for Worldwide, Evidence-based Research (mPower) — Seattle, Washington
- Automated Imaging Differentiation of Parkinsonism — Birmingham, Alabama
Explore by condition: All Parkinson Disease clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.