๐๏ธ Verified NIH Record โข Updated 2026-07-07
Eflornithine (DFMO) and Etoposide for Relapsed/Refractory Neuroblastoma (NCT04301843)
Phase II Trial of Eflornithine (DFMO) and Etoposide for Relapsed/Refractory Neuroblastoma
๐ต Active, Not Recruiting Phase2 ๐ Investigational Drug / Biologic Sponsor: Giselle Sholler
๐ฉบ Plain-English Summary (8th-Grade Level)
Difluoromethylornithine (DFMO) will be used in an open label, multicenter, study in combination with etoposide for subjects with relapsed/refractory neuroblastoma.
Who can join: Review the eligibility criteria below.
Location: University of Alabama/Children's of Alabama โ Birmingham, Alabama
Age range: Not specified to 31 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (31 Sites)
Showing the first 25 of 31 sites.
- University of Alabama/Children's of Alabama โ Birmingham, Alabama
- Arkansas Children's Hospital โ Little Rock, Arkansas
- UCSF Benioff Children's Hospital Oakland โ Oakland, California
- Rady Children's Hospital โ San Diego, California
- Connecticut Children's Hospital โ Hartford, Connecticut
- Arnold Palmer Hospital for Children โ Orlando, Florida
- St. Joseph's Children's Hospital โ Tampa, Florida
- Augusta University Health โ Augusta, Georgia
- University of Iowa โ Iowa City, Iowa
- Norton Children's Research Institute/Affiliated with University of Louisville School of Medicine โ Louisville, Kentucky
- Helen DeVos Children's Hospital โ Grand Rapids, Michigan
- Children's Hospital and Clinics of Minnesota โ Minneapolis, Minnesota
- Children's Mercy Hospitals and Clinics โ Kansas City, Missouri
- Cardinal Glennon Children's Hospital โ St Louis, Missouri
- Hackensack University Medical Center โ Hackensack, New Jersey
- Levine Children's Hospital โ Charlotte, North Carolina
- Cleveland Clinic Children's โ Cleveland, Ohio
- Randall Children's Hospital โ Portland, Oregon
- Penn State Milton S. Hershey Medical Center and Children's Hospital โ Hershey, Pennsylvania
- Hasbro Children's Hospital โ Providence, Rhode Island
- Medical University of South Carolina โ Charleston, South Carolina
- Dell Children's Blood and Cancer Center โ Austin, Texas
- Children's Medical Center Dallas โ Dallas, Texas
- Children's Hospital of The King's Daughters โ Norfolk, Virginia
- Medical College of Wisconsin โ Milwaukee, Wisconsin
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Neuroblastoma
- Open-Label Study of 18F-mFBG for Imaging Neuroblastoma โ Los Angeles, California
- Neuroblastoma Precision Trial โ Los Angeles, California
- Neuroblastoma Maintenance Therapy Trial โ Birmingham, Alabama
- Naxitamab for High-Risk Neuroblastoma Patients With Primary Refractory Disease or Incomplete Response to Salvage Treatment in Bone and/or Bone Marrow โ Indianapolis, Indiana
- A Study of N9 Chemotherapy in Children With Neuroblastoma โ New York, New York
- A Study of LY3295668 Erbumine in Participants With Relapsed/Refractory Neuroblastoma โ San Francisco, California
Explore by condition: All Neuroblastoma clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.