๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-07-07

Eflornithine (DFMO) and Etoposide for Relapsed/Refractory Neuroblastoma (NCT04301843)

Phase II Trial of Eflornithine (DFMO) and Etoposide for Relapsed/Refractory Neuroblastoma

๐Ÿ”ต Active, Not Recruiting Phase2 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Giselle Sholler

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

Difluoromethylornithine (DFMO) will be used in an open label, multicenter, study in combination with etoposide for subjects with relapsed/refractory neuroblastoma.

Who can join: Review the eligibility criteria below.

Location: University of Alabama/Children's of Alabama โ€” Birmingham, Alabama

Age range: Not specified to 31 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (31 Sites)

Showing the first 25 of 31 sites.

  • University of Alabama/Children's of Alabama โ€” Birmingham, Alabama
  • Arkansas Children's Hospital โ€” Little Rock, Arkansas
  • UCSF Benioff Children's Hospital Oakland โ€” Oakland, California
  • Rady Children's Hospital โ€” San Diego, California
  • Connecticut Children's Hospital โ€” Hartford, Connecticut
  • Arnold Palmer Hospital for Children โ€” Orlando, Florida
  • St. Joseph's Children's Hospital โ€” Tampa, Florida
  • Augusta University Health โ€” Augusta, Georgia
  • University of Iowa โ€” Iowa City, Iowa
  • Norton Children's Research Institute/Affiliated with University of Louisville School of Medicine โ€” Louisville, Kentucky
  • Helen DeVos Children's Hospital โ€” Grand Rapids, Michigan
  • Children's Hospital and Clinics of Minnesota โ€” Minneapolis, Minnesota
  • Children's Mercy Hospitals and Clinics โ€” Kansas City, Missouri
  • Cardinal Glennon Children's Hospital โ€” St Louis, Missouri
  • Hackensack University Medical Center โ€” Hackensack, New Jersey
  • Levine Children's Hospital โ€” Charlotte, North Carolina
  • Cleveland Clinic Children's โ€” Cleveland, Ohio
  • Randall Children's Hospital โ€” Portland, Oregon
  • Penn State Milton S. Hershey Medical Center and Children's Hospital โ€” Hershey, Pennsylvania
  • Hasbro Children's Hospital โ€” Providence, Rhode Island
  • Medical University of South Carolina โ€” Charleston, South Carolina
  • Dell Children's Blood and Cancer Center โ€” Austin, Texas
  • Children's Medical Center Dallas โ€” Dallas, Texas
  • Children's Hospital of The King's Daughters โ€” Norfolk, Virginia
  • Medical College of Wisconsin โ€” Milwaukee, Wisconsin

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Neuroblastoma clinical trials

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—