A Study Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use Disorder (NCT04375033)
CSP #2014 - Comparative Effectiveness of Two Formulations of Buprenorphine for Treating Opioid Use Disorder in Veterans (VA-BRAVE)
🩺 Plain-English Summary (8th-Grade Level)
VA-BRAVE will determine whether a 28-day long-acting injectable sub-cutaneous formulation of buprenorphine at a target dose of 300mg is superior in retaining Veterans in opioid treatment and in sustaining opioid abstinence compared to the daily sublingual (under the tongue) buprenorphine formulation at a target dose of 4-32 mg (standard of care). This is an open-label, randomized, controlled trial including 952 Veterans with opioid use disorder (OUD) recruited over 7 years and followed actively for 52 weeks. There are a number of secondary objectives that will be studied as well and include: comorbid substance use, both non-fatal and fatal opioid overdose, HIV and Hepatitis B (HBV) and C (HCV) testing results and risk behaviors, incarceration, quality of life, psychiatric symptoms of depression and posttraumatic stress disorder, housing status, dental health and utilization, and cost-effectiveness.
Who can join: Review the eligibility criteria below.
Location: Tuscaloosa VA Medical Center, Tuscaloosa, AL — Tuscaloosa, Alabama
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (25 Sites)
- Tuscaloosa VA Medical Center, Tuscaloosa, AL — Tuscaloosa, Alabama
- Phoenix VA Health Care System, Phoenix, AZ — Phoenix, Arizona
- VA Long Beach Healthcare System, Long Beach, CA — Long Beach, California
- VA Palo Alto Health Care System, Palo Alto, CA — Palo Alto, California
- San Francisco VA Medical Center, San Francisco, CA — San Francisco, California
- CERC (VISN1, West Haven, CT) — West Haven, Connecticut
- VA Connecticut Healthcare System West Haven Campus, West Haven, CT — West Haven, Connecticut
- Wilmington VA Medical Center, Wilmington, DE — Wilmington, Delaware
- Bay Pines VA Healthcare System, Pay Pines, FL — Bay Pines, Florida
- North Florida/South Georgia Veterans Health System, Gainesville, FL — Gainesville, Florida
- VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA — Boston, Massachusetts
- Minneapolis VA Health Care System, Minneapolis, MN — Minneapolis, Minnesota
- Louis Stokes VA Medical Center, Cleveland, OH — Cleveland, Ohio
- Dayton VA Medical Center, Dayton, OH — Dayton, Ohio
- Philadelphia MultiService Center, Philadelphia, PA — Philadelphia, Pennsylvania
- VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA — Pittsburgh, Pennsylvania
- Providence VA Medical Center, Providence, RI — Providence, Rhode Island
- VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX — Dallas, Texas
- VA Salt Lake City Health Care System, Salt Lake City, UT — Salt Lake City, Utah
- White River Junction VA Medical Center, White River Junction, VT — White River Junction, Vermont
- Hampton VA Medical Center, Hampton, VA — Hampton, Virginia
- Salem VA Medical Center, Salem, VA — Salem, Virginia
- VA Puget Sound Health Care System Seattle Division, Seattle, WA — Seattle, Washington
- Huntington VA Medical Center, Huntington, WV — Huntington, West Virginia
- Clement J. Zablocki VA Medical Center, Milwaukee, WI — Milwaukee, Wisconsin
📞 Contact the Study Coordinator
Phone: (857) 364-2888
Email: avron.spiro@va.gov
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Opioid Use Disorder
- Therapy and Peer Support for Patients Taking Medication for Opioid Use Disorder — Atlantic City, New Jersey
- The Emergency Department Longitudinal Integrated Care — Seattle, Washington
- Virtual Reality Cognitive-Affective Training for Opioid Use Disorder- A Phase 2 RCT — La Jolla, California
- Extended-release Buprenorphine as a Novel Low-dose Induction Strategy — Boston, Massachusetts
- Healing Opioid Misuse and Pain Through Engagement (HOPE) Trial — Ann Arbor, Michigan
- Telemedicine XR-B for Individuals in Jail — Cumberland, Maryland
Explore by condition: All Opioid Use Disorder clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.