🏛️ Verified NIH Record • Updated 2026-08-27

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation (NCT04449874)

A Phase Ia/Ib Dose-Escalation and Dose-Expansion Study Evaluating the Safety, Pharmacokinetics, and Activity of GDC-6036 as a Single Agent and in Combination With Other Anti-cancer Therapies in Patients With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation

🔵 Active, Not Recruiting Phase1 💊 Investigational Drug / Biologic Sponsor: Genentech, Inc.

🩺 Plain-English Summary (8th-Grade Level)

This is a Phase I dose-escalation and dose-expansion study that will evaluate the safety, pharmacokinetics (PK), and preliminary activity of GDC-6036 in patients with advanced or metastatic solid tumors with a KRAS G12C mutation.

Who can join: Review the eligibility criteria below.

Location: City of Hope Comprehensive Cancer Center — Duarte, California

Age range: 18 Years

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (63 Sites)

Showing the first 25 of 63 sites.

  • City of Hope Comprehensive Cancer Center — Duarte, California
  • UCSD Moores Cancer Center — La Jolla, California
  • Chao Family Comprehensive Cancer Center UCI — Orange, California
  • Yale Cancer Center — New Haven, Connecticut
  • Florida Cancer Specialists - Sarasota — Sarasota, Florida
  • Dana Farber Cancer Institute — Boston, Massachusetts
  • Memorial Sloan Kettering Cancer Center — New York, New York
  • University of Oklahoma — Oklahoma City, Oklahoma
  • UPMC - Hillman Cancer Center — Pittsburgh, Pennsylvania
  • Slade Health Inward goods — Mount Kuring-Gai, New South Wales
  • Peter MacCallum Cancer Center — Melbourne, Victoria
  • Alfred Health — Melbourne, Victoria
  • Linear Clinical Research Limited — Nedlands, Western Australia
  • UZ Antwerpen — Edegem,
  • CHU de Liège — Liège,
  • AZ St Maarten Campus Leopoldstr — Mechelen,
  • Santa Casa de Misericordia de Belo Horizonte - PPDS — Belo Horizonte, Minas Gerais
  • Hospital Erasto Gaertner — Curitiba, Paraná
  • Hospital de Clinicas de Porto Alegre HCPA PPDS — Porto Alegre, Pará
  • Universidade de Caxias do Sul — Caxias do Sul, Rio Grande do Sul
  • Hospital Sao Lucas Da Pontificia Universidade Catolica Do Rio Grande Do Sul (PUCRS) — Porto Alegre, Rio Grande do Sul
  • Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto Hospital de Base - PPDS — São José do Rio Preto, São Paulo
  • Instituto Nacional de Câncer — Rio de Janeiro,
  • Ottawa Hospital — Ottawa, Ontario
  • Princess Margaret Cancer Centre — Toronto, Ontario

📞 Contact the Study Coordinator

Phone: (800) 826-4673

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗