A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation (NCT04449874)
A Phase Ia/Ib Dose-Escalation and Dose-Expansion Study Evaluating the Safety, Pharmacokinetics, and Activity of GDC-6036 as a Single Agent and in Combination With Other Anti-cancer Therapies in Patients With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation
🩺 Plain-English Summary (8th-Grade Level)
This is a Phase I dose-escalation and dose-expansion study that will evaluate the safety, pharmacokinetics (PK), and preliminary activity of GDC-6036 in patients with advanced or metastatic solid tumors with a KRAS G12C mutation.
Who can join: Review the eligibility criteria below.
Location: City of Hope Comprehensive Cancer Center — Duarte, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (63 Sites)
Showing the first 25 of 63 sites.
- City of Hope Comprehensive Cancer Center — Duarte, California
- UCSD Moores Cancer Center — La Jolla, California
- Chao Family Comprehensive Cancer Center UCI — Orange, California
- Yale Cancer Center — New Haven, Connecticut
- Florida Cancer Specialists - Sarasota — Sarasota, Florida
- Dana Farber Cancer Institute — Boston, Massachusetts
- Memorial Sloan Kettering Cancer Center — New York, New York
- University of Oklahoma — Oklahoma City, Oklahoma
- UPMC - Hillman Cancer Center — Pittsburgh, Pennsylvania
- Slade Health Inward goods — Mount Kuring-Gai, New South Wales
- Peter MacCallum Cancer Center — Melbourne, Victoria
- Alfred Health — Melbourne, Victoria
- Linear Clinical Research Limited — Nedlands, Western Australia
- UZ Antwerpen — Edegem,
- CHU de Liège — Liège,
- AZ St Maarten Campus Leopoldstr — Mechelen,
- Santa Casa de Misericordia de Belo Horizonte - PPDS — Belo Horizonte, Minas Gerais
- Hospital Erasto Gaertner — Curitiba, Paraná
- Hospital de Clinicas de Porto Alegre HCPA PPDS — Porto Alegre, Pará
- Universidade de Caxias do Sul — Caxias do Sul, Rio Grande do Sul
- Hospital Sao Lucas Da Pontificia Universidade Catolica Do Rio Grande Do Sul (PUCRS) — Porto Alegre, Rio Grande do Sul
- Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto Hospital de Base - PPDS — São José do Rio Preto, São Paulo
- Instituto Nacional de Câncer — Rio de Janeiro,
- Ottawa Hospital — Ottawa, Ontario
- Princess Margaret Cancer Centre — Toronto, Ontario
📞 Contact the Study Coordinator
Phone: (800) 826-4673
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.