INCB000928 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Anemia Due to Myeloproliferative Disorders (NCT04455841)
A Phase 1/2 Open-Label, Multicenter Study of INCB000928 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Anemia Due to Myeloproliferative Disorders
๐ฉบ Plain-English Summary (8th-Grade Level)
This Phase 1/2, open-label, dose-finding study is intended to evaluate the safety and tolerability, PK, PD, and efficacy of INCB000928 administered as monotherapy or in combination with ruxolitinib in participants with MF who are transfusion-dependent or presenting with symptomatic anemia. This study will consist of 2 parts: dose escalation and expansion.
Who can join: Review the eligibility criteria below.
Location: City of Hope National Medical Center โ Duarte, California
Age range: 18 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (34 Sites)
Showing the first 25 of 34 sites.
- City of Hope National Medical Center โ Duarte, California
- City of Hope Orange County โ Irvine, California
- Usc Norris Comprehensive Cancer Center โ Los Angeles, California
- Stanford Cancer Center โ Palo Alto, California
- Prebys Cancer Center โ San Diego, California
- Emory University - Winship Cancer Institute โ Atlanta, Georgia
- Emory University-Winship Cancer Institute โ Atlanta, Georgia
- Start Midwest โ Grand Rapids, Michigan
- Washington University School of Medicine โ St Louis, Missouri
- Weill Cornell Medical Centers โ New York, New York
- Duke University Medical Center, Department of Hematologic Malignancies and Cellular Therapy โ Durham, North Carolina
- Vanderbilt University Medical Center โ Nashville, Tennessee
- Md Anderson Cancer Center โ Houston, Texas
- Princess Margaret Cancer Center โ Toronto, Ontario
- McGill University Jewish General Hospital โ Montreal, Quebec
- Centre Hospitalier D'Angers โ Angers,
- Institut Paoli Calmettes โ Marseille,
- Hospital Saint Louis โ Paris,
- Azienda Ospedaliera Papa Giovanni Xxiii โ Bergamo,
- S Orsolas University Hospital Seragnoli Institute of Hematology โ Bologna,
- Azienda Ospedaliero-Universitaria Careggi (Aouc) โ Florence,
- Azienda Ospedaliera Universitaria San Luigi Gonzaga Orbassano โ Orbassano,
- Comitato Di Bioetica Della Fondazione Irccs Policlinico San Matteo โ Pavia,
- Ospedale Santa Maria Della Misericordia Perugia โ Perugia,
- Tokyo Medical and Dental University Hospital โ Bunkyล City,
๐ Contact the Study Coordinator
Phone: (800) 826-4673
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.