Sirolimus in Combination With Metronomic Chemotherapy in Children With High-Risk Solid Tumors (NCT04469530)
A Maintenance Protocol of Sirolimus in Combination With Metronomic Chemotherapy in Children With High-Risk Solid Tumors
🩺 Plain-English Summary (8th-Grade Level)
The primary objective of this study is to improve the 2-year progression-free survival in children with high-risk solid tumors who are administered a maintenance regimen with continuous sirolimus administered on a backbone of metronomic chemotherapy following the completion of "standard" therapy, as compared to high-risk solid tumor patients treated with observation alone following completion of "standard" therapy.
Who can join: Review the eligibility criteria below.
Location: Aflac Cancer & Blood Disorders Centers — Atlanta, Georgia
Age range: 1 Year to 30 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (5 Sites)
- Aflac Cancer & Blood Disorders Centers — Atlanta, Georgia
- Children's Healthcare of Atlanta — Atlanta, Georgia
- Washington University School of Medicine — St Louis, Missouri
- Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center (UPMC) — Pittsburgh, Pennsylvania
- Texas Children's Cancer Center — Houston, Texas
📞 Contact the Study Coordinator
Phone: (404) 785-1651
Email: Kathryn.Sutton@choa.org
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.