🏛️ Verified NIH Record • Updated 2026-02-05
A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors (NCT04478279)
A Phase 1-2 Dose-escalation and Expansion Study of ST101 in Patients With Advanced Unresectable and Metastatic Solid Tumors
🔵 Active, Not Recruiting Phase1 / Phase2 💊 Investigational Drug / Biologic Sponsor: Sapience Therapeutics
🩺 Plain-English Summary (8th-Grade Level)
This is an open-label, two-part, phase 1-2 dose-finding study designed to determine the safety, tolerability, PK, PD, and proof-of-concept efficacy of ST101 administered IV in patients with advanced solid tumors. The study consists of two phases: a phase 1 dose escalation/regimen exploration phase and a phase 2 expansion phase.
Who can join: Review the eligibility criteria below.
Location: University of California, San Francisco — San Francisco, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (11 Sites)
- University of California, San Francisco — San Francisco, California
- Sarah Cannon Research Institute — Denver, Colorado
- Northwestern Medicine Cancer Centers — Warrenville, Illinois
- START Midwest — Grand Rapids, Michigan
- Columbia University — New York, New York
- Duke University School of Medicine — Durham, North Carolina
- Sarah Cannon Research Institute — Nashville, Tennessee
- Edinburgh Cancer Centre — Edinburgh,
- The Beaston West of Scotland Cancer Centre — Glasgow,
- University of Leeds — Leeds,
- Sarah Cannon Research Institute UK — London,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.