I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients (NCT04488081)
I-SPY COVID TRIAL: An Adaptive Platform Trial to Reduce Mortality and Ventilator Requirements for Critically Ill Patients
🩺 Plain-English Summary (8th-Grade Level)
The goal of this project is to rapidly screen promising agents, in the setting of an adaptive platform trial, for treatment of critically ill COVID-19 patients. In this phase 2 platform design, agents will be identified with a signal suggesting a big impact on reducing mortality and the need for, as well as duration, of mechanical ventilation.
Who can join: Review the eligibility criteria below.
Location: University of Alabama at Birmingham — Birmingham, Alabama
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (36 Sites)
Showing the first 25 of 36 sites.
- University of Alabama at Birmingham — Birmingham, Alabama
- UC Davis Medical Center — Davis, California
- UC Irvine Medical Center — Irvine, California
- Long Beach Memorial Medical Center — Long Beach, California
- Kaiser LAMC — Los Angeles, California
- University of Southern California — Los Angeles, California
- Hoag Memorial Hospital Presbyterian — Newport Beach, California
- University of California San Francisco (UCSF) — San Francisco, California
- University of Colorado — Aurora, Colorado
- Yale Cancer Center — New Haven, Connecticut
- Stamford Health — Stamford, Connecticut
- Georgetown University — Washington D.C., District of Columbia
- University of Miami — Coral Gables, Florida
- University of Florida — Gainesville, Florida
- Emory University — Atlanta, Georgia
- Northwestern University — Chicago, Illinois
- University of Iowa — Iowa City, Iowa
- University of Michigan — Ann Arbor, Michigan
- Corewell Health — Grand Rapids, Michigan
- Mercy Hospital Springfield — Springfield, Missouri
- Kalispell Regional Medical Center — Kalispell, Montana
- Logan Health Medical Center — Kalispell, Montana
- Virtua Mount Holly Hospital — Mount Holly, New Jersey
- Virtua Voorhees Hospital — Voorhees Township, New Jersey
- Columbia University Medical Center — New York, New York
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in COVID-19
- COVID-19 and Cancer Consortium Registry — Nashville, Tennessee
- Impact of Immunosuppression Adjustment on COVID-19 Vaccination Response in Kidney Transplant Recipients — Sacramento, California
- COVID-19, Chronic Adaptation and Response to Exercise (COVID-CARE) — Bethesda, Maryland
- Identification and Characterization of SARS-CoV-2 Specific CD8 T Cells in Humans — Baltimore, Maryland
- Canadian Adaptive Platform Trial of Treatments for COVID-19 in Community Settings — Calgary, Alberta
- A Nasal Treatment for COVID-19 — Indianapolis, Indiana
Explore by condition: All COVID-19 clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.