Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease (NCT04508088)
🩺 Plain-English Summary (8th-Grade Level)
The investigators will be evaluating bone marrow composition via magnetic resonance imaging in newly diagnosed adolescents with Crohn disease (CD) compared to healthy, matched controls. The investigators will also be assessing their bone mineral density via other imaging modalities, including dual-energy X-ray absorptiometry and peripheral quantitative computed tomography. This longitudinal project will focus on abnormalities in bone marrow composition, and specifically whether adolescents with newly diagnosed CD exhibit increased bone marrow fat, its association with bone mineral density (BMD) and the underlying pathophysiology, including bone turnover markers and immune cellular/molecular parameters.
Who can join: Review the eligibility criteria below.
Location: Boston Children's Hospital — Boston, Massachusetts
Age range: 13 Years to 20 Years
🧪 Interventions in This Study
- Coronal T1 weighted spin echo images (DIAGNOSTIC_TEST)
- Spin-lattice relaxation (T1) (DIAGNOSTIC_TEST)
- Magnetic resonance spectroscopy (DIAGNOSTIC_TEST)
- Blood Draw (DIAGNOSTIC_TEST)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Boston Children's Hospital — Boston, Massachusetts
📞 Contact the Study Coordinator
Phone: (617) 355-7476
Email: rebecca.gordon@childrens.harvard.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Inflammatory Bowel Disease
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- Multi-Center African-American Inflammatory Bowel Disease Study (MAAIS) — Baltimore, Maryland
- The EDICT Trial - Therapy for Inflammatory Bowel Disease Flares — Winston-Salem, North Carolina
- Longitudinal Immunophenotyping of Patients With Inflammatory Bowel Disease — Bethesda, Maryland
- Immune Regulation in Ulcerative Colitis or Crohn s Disease — Bethesda, Maryland
- A Randomized Crossover Trial of Bright Light Therapy in Crohn's Disease on Intestinal Barrier Homeostasis — Chicago, Illinois
Explore by condition: All Inflammatory Bowel Disease clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.