🏛️ Verified NIH Record • Updated 2025-07-24
A Study to Evaluate MEDI5752 and Axitinib in Subjects With Advanced Renal Cell Carcinoma (NCT04522323)
A Phase 1b, Open-label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Antitumor Activity of MEDI5752 in Combination With Axitinib in Subjects With Advanced Renal Cell Carcinoma
🔵 Active, Not Recruiting Phase1 💊 Investigational Drug / Biologic Sponsor: MedImmune LLC
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to evaluate MEDI5752 in combination with Lenvatinib (or Axitinib), in subjects with advanced renal cell carcinoma.
Who can join: Review the eligibility criteria below.
Location: Research Site — Washington D.C., District of Columbia
Age range: 18 Years to 101 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (20 Sites)
- Research Site — Washington D.C., District of Columbia
- Research Site — Fort Myers, Florida
- Research Site — St Louis, Missouri
- Research Site — New York, New York
- Research Site — Cleveland, Ohio
- Research Site — Hershey, Pennsylvania
- Research Site — Nashville, Tennessee
- Research Site — Frankston,
- Research Site — Waratah,
- Research Site — Villejuif,
- Research Site — Barcelona,
- Research Site — Barcelona,
- Research Site — Barcelona,
- Research Site — Barcelona,
- Research Site — Córdoba,
- Research Site — Madrid,
- Research Site — Madrid,
- Research Site — Sabadell,
- Research Site — Seville,
- Research Site — Valencia,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Advanced Renal Cell Carcinoma
- Testing the Addition of a New Anti-cancer Drug, Radium-223 Dichloride, to the Usual Treatment (Cabozantinib) for Advanced Renal Cell Cancer That Has Spread to the Bone, RadiCaL Study — Birmingham, Alabama
- Trial of Zanzalintinib (XL092) in Combination With Immunotherapy in Patients Who Progress on Adjuvant Therapy in Clear Cell RCC — La Jolla, California
- Sitagliptin With Pembro in RCC and Melanoma — Iowa City, Iowa
Explore by condition: All Advanced Renal Cell Carcinoma clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.