Basket Study of Tucatinib and Trastuzumab in Solid Tumors With HER2 Alterations (NCT04579380)
A Phase 2 Basket Study of Tucatinib in Combination With Trastuzumab in Subjects With Previously Treated, Locally Advanced Unresectable or Metastatic Solid Tumors Driven by HER2 Alterations
🩺 Plain-English Summary (8th-Grade Level)
This trial studies how well tucatinib works for solid tumors that make either more HER2 or a different type of HER2 than usual (HER2 alterations) The solid tumors studied in this trial have either spread to other parts of the body (metastatic) or cannot be removed completely with surgery (unresectable). All participants will get both tucatinib and trastuzumab. People with hormone-receptor positive breast cancer will also get a drug called fulvestrant. The trial will also look at what side effects happen. A side effect is anything a drug does besides treating cancer.
Who can join: Review the eligibility criteria below.
Location: HonorHealth — Phoenix, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (108 Sites)
Showing the first 25 of 108 sites.
- HonorHealth — Phoenix, Arizona
- HonorHealth — Tempe, Arizona
- The University of Arizona Cancer Center-North Campus — Tucson, Arizona
- City of Hope at Huntington Beach — Huntington Beach, California
- City of Hope at Irvine Sand Canyon — Irvine, California
- Koman Family Outpatient Pavilion — La Jolla, California
- UC San Diego Medical Center - La Jolla (Jacobs Medical Center / Thornton Pavilion) — La Jolla, California
- UC San Diego Moores Cancer Center- Investigational Drug Services — La Jolla, California
- UC San Diego Moores Cancer Center — La Jolla, California
- City of Hope at Long Beach Worsham — Long Beach, California
- City of Hope at Long Beach Elm — Long Beach, California
- City of Hope at Newport Beach Lido — Newport Beach, California
- City of Hope Torrance — Torrance, California
- Rocky Mountain Cancer Centers — Aurora, Colorado
- Rocky Mountain Cancer Centers — Boulder, Colorado
- Rocky Mountain Cancer Centers — Thornton, Colorado
- Moffitt Cancer Center — Tampa, Florida
- Minnesota Oncology Hematology, PA — Coon Rapids, Minnesota
- Drug Storage and Regulatory location: MMCORC — Saint Louis Park, Minnesota
- Metro Minnesota Community Oncology Research Consortium (MMCORC) — Saint Louis Park, Minnesota
- Washington University School of Medicine - Obstetrics & Gynecology [Academic Offices) — St Louis, Missouri
- Barnes-Jewish Hospital Investigational Drug Pharmacy (IDS) — St Louis, Missouri
- Washington University School of Medicine - Obstetrics & Gynecology — St Louis, Missouri
- Washington University School of Medicine [Patient Clinics] — St Louis, Missouri
- Oncology Hematology West P.C. dba Nebraska Cancer Specialists — Omaha, Nebraska
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
Explore by condition: All Uterine Neoplasms clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.