Meditation Accelerated Brain Stimulation for Depression (NCT04586699)
🩺 Plain-English Summary (8th-Grade Level)
Repetitive Transcranial magnetic stimulation (rTMS) is an FDA-approved treatment for depression that involves brief magnetic stimulation pulses on the dorsolateral prefrontal cortex (DLPFC) brain region. The ultimate goal of this treatment is to increase excitability and long-term plasticity in DLPFC, a brain region shown to be hypo-active in depression. Unfortunately, rTMS only has low to moderate efficacy; remission rates for patients range from \~15-30% in large randomized controlled trials. The focus of this research is to develop a next-generation rTMS protocol that is guided by the basic principles underlying brain plasticity, in order to improve the efficacy of rTMS for the treatment of depression. Specifically, in this study the investigators will test rTMS paired with a depression-relevant cognitive state of internal attention.
Who can join: Review the eligibility criteria below.
Location: Neuromodulation Clinic Veterans Affairs San Diego — San Diego, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (2 Sites)
- Neuromodulation Clinic Veterans Affairs San Diego — San Diego, California
- UC San Diego Health Psychiatry — San Diego, California
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Depression
- Neural Circuit Biomarkers of Transcranial Magnetic Stimulation Study — Stanford, California
- A Behavioral Activation Prenatal and Postpartum Intervention for Depressed Pregnant Smokers — Houston, Texas
- EEG Biomarker Study for Participants in the Neurolief "MOOD" Trial — Providence, Rhode Island
- Using rTMS to Treat Depression — Miami, Florida
- Integrating Ketamine Effects on Neuronal Molecular Signatures and the Brain Functional and Structural Connectome — Boston, Massachusetts
Explore by condition: All Depression clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.