🏛️ Verified NIH Record • Updated 2026-06-16

A Study of AZD0486 in Subjects With B-Cell Non-Hodgkin Lymphoma (NCT04594642)

A Multicenter, Phase 1, Open-label, Dose-escalation and Expansion Study of AZD0486, a Bispecific Antibody Targeting CD19 in Subjects With B-Cell Non-Hodgkin Lymphoma

🔵 Active, Not Recruiting Phase1 💊 Investigational Drug / Biologic Sponsor: AstraZeneca

🩺 Plain-English Summary (8th-Grade Level)

This phase 1 study will investigate the safety, tolerability, pharmacokinetic, pharmacodynamic, and clinical activity of AZD0486, a CD19 x CD3 T-cell engaging bispecific antibody, in subjects with B-cell non-Hodgkin lymphoma (B-NHL).

Who can join: Review the eligibility criteria below.

Location: Research Site — Tampa, Florida

Age range: 18 Years to 130 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (25 Sites)

  • Research Site — Tampa, Florida
  • Research Site — Louisville, Kentucky
  • Research Site — New Brunswick, New Jersey
  • Research Site — Charlotte, North Carolina
  • Research Site — Columbus, Ohio
  • Research Site — Pittsburgh, Pennsylvania
  • Research Site — Austin, Texas
  • Research Site — Houston, Texas
  • Research Site — Milwaukee, Wisconsin
  • Research Site — Heidelberg,
  • Research Site — Hobart,
  • Research Site — Melbourne,
  • Research Site — Chūōku,
  • Research Site — Kōtoku,
  • Research Site — Nagoya,
  • Research Site — Yamagata,
  • Research Site — Seoul,
  • Research Site — Seoul,
  • Research Site — Seoul,
  • Research Site — Seoul,
  • Research Site — Seoul,
  • Research Site — Kaohsiung City,
  • Research Site — Kweishan,
  • Research Site — Tainan,
  • Research Site — Taipei,

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

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💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗