Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer (NCT04628767)
A Phase II/III Trial of Durvalumab and Chemotherapy for Patients With High Grade Upper Tract Urothelial Cancer Prior to Nephroureterectomy
🩺 Plain-English Summary (8th-Grade Level)
This phase II/III trial compares the effect of adding durvalumab to chemotherapy versus chemotherapy alone before surgery in treating patients with upper urinary tract cancer. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as methotrexate, vinblastine, doxorubicin, cisplatin, and gemcitabine work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Durvalumab in combination with chemotherapy before surgery may enhance the shrinking of the tumor compared to chemotherapy alone.
Who can join: Review the eligibility criteria below.
Location: Kingman Regional Medical Center — Kingman, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (257 Sites)
Showing the first 25 of 257 sites.
- Kingman Regional Medical Center — Kingman, Arizona
- Mercy Hospital Fort Smith — Fort Smith, Arkansas
- University of Arkansas for Medical Sciences — Little Rock, Arkansas
- Sutter Auburn Faith Hospital — Auburn, California
- Alta Bates Summit Medical Center-Herrick Campus — Berkeley, California
- City of Hope Comprehensive Cancer Center — Duarte, California
- Palo Alto Medical Foundation-Fremont — Fremont, California
- UC San Diego Moores Cancer Center — La Jolla, California
- Memorial Medical Center — Modesto, California
- Palo Alto Medical Foundation-Camino Division — Mountain View, California
- Palo Alto Medical Foundation Health Care — Palo Alto, California
- Stanford Cancer Institute Palo Alto — Palo Alto, California
- Sutter Roseville Medical Center — Roseville, California
- Sutter Medical Center Sacramento — Sacramento, California
- UC San Diego Medical Center - Hillcrest — San Diego, California
- California Pacific Medical Center-Pacific Campus — San Francisco, California
- Palo Alto Medical Foundation-Santa Cruz — Santa Cruz, California
- Sutter Pacific Medical Foundation — Santa Rosa, California
- Palo Alto Medical Foundation-Sunnyvale — Sunnyvale, California
- Sutter Solano Medical Center/Cancer Center — Vallejo, California
- UCHealth University of Colorado Hospital — Aurora, Colorado
- UCHealth - Cherry Creek — Denver, Colorado
- Poudre Valley Hospital — Fort Collins, Colorado
- Cancer Care and Hematology-Fort Collins — Fort Collins, Colorado
- UCHealth Greeley Hospital — Greeley, Colorado
📞 Contact the Study Coordinator
Phone: (702) 384-0013
Email: research@sncrf.org
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Renal Pelvis and Ureter Urothelial Carcinoma
- Pembrolizumab and Enfortumab Vedotin With Pembrolizumab Prior to and After Radical Nephroureterectomy for High-Risk Upper Tract Urothelial Cancer — Los Angeles, California
- Office-Based Ureteroscopy Utilizing a Single Use Digital, Flexible Ureteroscope for Upper Tract Urothelial Carcinoma — Ann Arbor, Michigan
Explore by condition: All Renal Pelvis and Ureter Urothelial Carcinoma clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.