🏛️ Verified NIH Record • Updated 2026-07-01

ET140203 T Cells in Pediatric Subjects With Hepatoblastoma, HCN-NOS, or Hepatocellular Carcinoma (NCT04634357)

An Open-Label, Dose Escalation, Phase I/II Clinical Trial of ET140203 T Cells in Pediatric Subjects With Relapsed/Refractory Hepatoblastoma (HB), Hepatocellular Neoplasm-Not Otherwise Specified (HCN-NOS), or Hepatocellular Carcinoma (HCC)

🟢 Recruiting Phase1 / Phase2 💊 Investigational Drug / Biologic Sponsor: Eureka Therapeutics Inc.

🩺 Plain-English Summary (8th-Grade Level)

Open-label, dose escalation, multi-center, Phase I/II clinical trial to assess the safety/tolerability and determine the recommended Phase II Dose (RP2D) of ET140203 T-cells in pediatric subjects who are AFP-positive/HLA-A2-positive and have relapsed/refractory HB, HCN-NOS, or HCC.

Who can join: Review the eligibility criteria below.

Location: Children's Hospital Los Angeles — Los Angeles, California

Age range: 1 Year to 21 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (4 Sites)

  • Children's Hospital Los Angeles — Los Angeles, California
  • Children's Hospital Orange County — Orange, California
  • UCSF Benioff Children's Hospitals — San Francisco, California
  • Dana-Farber/Boston Children's Cancer and Blood Disorders Center — Boston, Massachusetts

📞 Contact the Study Coordinator

Phone: (510) 722-8719

Email: Teresa.Klask@eurekainc.com

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

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💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗