๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-08-10

DFMO as Maintenance Therapy for Molecular High/Very High Risk and Relapsed Medulloblastoma (NCT04696029)

Phase II Trial of Eflornithine/DFMO as Maintenance Therapy for Molecular High Risk/Very High Risk and Relapsed/Refractory Medulloblastoma

๐ŸŸข Recruiting Phase2 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Giselle Sholler

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

Difluoromethylornithine (DFMO) will be used in an open label, multicenter, study as Maintenance Therapy for Molecular High Risk/Very High Risk and Relapsed/Refractory Medulloblastoma.

Who can join: Review the eligibility criteria below.

Location: Arkansas Children's Hospital โ€” Little Rock, Arkansas

Age range: Not specified to 21 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (26 Sites)

Showing the first 25 of 26 sites.

  • Arkansas Children's Hospital โ€” Little Rock, Arkansas
  • UCSF Benioff Children's Hospital Oakland โ€” Oakland, California
  • UC Davis Comprehensive Cancer Center โ€” Sacramento, California
  • Rady Children's Hospital โ€” San Diego, California
  • Stanford University โ€” Stanford, California
  • Connecticut Children's Hospital โ€” Hartford, Connecticut
  • Nicklaus Children's Hospital โ€” Miami, Florida
  • Arnold Palmer Hospital for Children โ€” Orlando, Florida
  • All Children's Hospital Johns Hopkins Medicine โ€” St. Petersburg, Florida
  • St. Joseph's Children's Hospital โ€” Tampa, Florida
  • Kapiolani Medical Center for Women and Children โ€” Honolulu, Hawaii
  • Advocate Aurora Research Institute โ€” Chicago, Illinois
  • Kentucky Children's Hospital โ€” Lexington, Kentucky
  • Norton Children's Research Institute/Affiliated with University of Louisville School of Medicine โ€” Louisville, Kentucky
  • Children's Mercy Hospitals and Clinics โ€” Kansas City, Missouri
  • Cardinal Glennon Children's Medical Center โ€” St Louis, Missouri
  • Hackensack University Medical Center โ€” Hackensack, New Jersey
  • Levine Children's Hospital โ€” Charlotte, North Carolina
  • Duke University โ€” Durham, North Carolina
  • University of Oklahoma โ€” Oklahoma City, Oklahoma
  • Randall Children's Hospital โ€” Portland, Oregon
  • Penn State Milton S. Hershey Medical Center and Children's Hospital โ€” Hershey, Pennsylvania
  • Hasbro Children's Hospital โ€” Providence, Rhode Island
  • Medical University of South Carolina โ€” Charleston, South Carolina
  • Dell Children's Blood and Cancer Center โ€” Austin, Texas

๐Ÿ“ž Contact the Study Coordinator

Phone: (717) 531-0003

Email: BCCEnroll@pennstatehealth.psu.edu

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Medulloblastoma clinical trials

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—