DFMO as Maintenance Therapy for Molecular High/Very High Risk and Relapsed Medulloblastoma (NCT04696029)
Phase II Trial of Eflornithine/DFMO as Maintenance Therapy for Molecular High Risk/Very High Risk and Relapsed/Refractory Medulloblastoma
๐ฉบ Plain-English Summary (8th-Grade Level)
Difluoromethylornithine (DFMO) will be used in an open label, multicenter, study as Maintenance Therapy for Molecular High Risk/Very High Risk and Relapsed/Refractory Medulloblastoma.
Who can join: Review the eligibility criteria below.
Location: Arkansas Children's Hospital โ Little Rock, Arkansas
Age range: Not specified to 21 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (26 Sites)
Showing the first 25 of 26 sites.
- Arkansas Children's Hospital โ Little Rock, Arkansas
- UCSF Benioff Children's Hospital Oakland โ Oakland, California
- UC Davis Comprehensive Cancer Center โ Sacramento, California
- Rady Children's Hospital โ San Diego, California
- Stanford University โ Stanford, California
- Connecticut Children's Hospital โ Hartford, Connecticut
- Nicklaus Children's Hospital โ Miami, Florida
- Arnold Palmer Hospital for Children โ Orlando, Florida
- All Children's Hospital Johns Hopkins Medicine โ St. Petersburg, Florida
- St. Joseph's Children's Hospital โ Tampa, Florida
- Kapiolani Medical Center for Women and Children โ Honolulu, Hawaii
- Advocate Aurora Research Institute โ Chicago, Illinois
- Kentucky Children's Hospital โ Lexington, Kentucky
- Norton Children's Research Institute/Affiliated with University of Louisville School of Medicine โ Louisville, Kentucky
- Children's Mercy Hospitals and Clinics โ Kansas City, Missouri
- Cardinal Glennon Children's Medical Center โ St Louis, Missouri
- Hackensack University Medical Center โ Hackensack, New Jersey
- Levine Children's Hospital โ Charlotte, North Carolina
- Duke University โ Durham, North Carolina
- University of Oklahoma โ Oklahoma City, Oklahoma
- Randall Children's Hospital โ Portland, Oregon
- Penn State Milton S. Hershey Medical Center and Children's Hospital โ Hershey, Pennsylvania
- Hasbro Children's Hospital โ Providence, Rhode Island
- Medical University of South Carolina โ Charleston, South Carolina
- Dell Children's Blood and Cancer Center โ Austin, Texas
๐ Contact the Study Coordinator
Phone: (717) 531-0003
Email: BCCEnroll@pennstatehealth.psu.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Medulloblastoma
- Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients With Newly Diagnosed WNT-Driven Medulloblastoma โ Birmingham, Alabama
- A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma โ Palo Alto, California
- A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma โ Los Angeles, California
- HeadStart4: Newly Diagnosed Children (<10 y/o) With Medulloblastoma and Other CNS Embryonal Tumors โ Birmingham, Alabama
- Comparison of Neurocognitive Outcome in Two Standard Regimen for Treatment of Low-risk Medulloblastoma โ Birmingham, Alabama
- Liothyronine in Combination With BIT Regimen for Medulloblastoma With or Without Minimal Residual Disease โ San Francisco, California
Explore by condition: All Medulloblastoma clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.