🏛️ Verified NIH Record • Updated 2026-06-29

Valemetostat Tosylate (DS-3201b), an Enhancer of Zeste Homolog (EZH) 1/2 Dual Inhibitor, for Relapsed/Refractory Peripheral T-Cell Lymphoma (VALENTINE-PTCL01) (NCT04703192)

Single-arm, Phase 2 Study of Valemetostat Tosylate Monotherapy in Subjects With Relapsed/Refractory Peripheral T-Cell Lymphoma (VALENTINE-PTCL01)

🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: Daiichi Sankyo

🩺 Plain-English Summary (8th-Grade Level)

This study will characterize the safety and clinical benefit of valemetostat tosylate in participants with relapsed/refractory peripheral T-cell lymphoma, including relapsed/refractory adult T-cell leukemia/lymphoma.

Who can join: Review the eligibility criteria below.

Location: City Of Hope National Medical Center — Duarte, California

Age range: 18 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (60 Sites)

Showing the first 25 of 60 sites.

  • City Of Hope National Medical Center — Duarte, California
  • Stanford University Medical Center - Cancer Clinical Trials Office - ONCOLOGY — Palo Alto, California
  • University of California San Francisco — San Francisco, California
  • University Of Colorado Cancer Center — Aurora, Colorado
  • Emory University Hospital - Winship Cancer Institute — Atlanta, Georgia
  • Northwestern University - Feinberg School of Medicine — Chicago, Illinois
  • Dana Farber Cancer Institute — Boston, Massachusetts
  • Mayo Clinic - Rochester — Rochester, Minnesota
  • Washington University School of Medicine — St Louis, Missouri
  • Hackensack University Medical Center - John Theurer Cancer Center — Hackensack, New Jersey
  • Memorial Sloan-Kettering Cancer Center at Memorial Hospital — New York, New York
  • Weill Cornell Medicine — New York, New York
  • Duke Cancer Center — Durham, North Carolina
  • University of Pennsylvania Perelman Center for Advanced Medicine — Philadelphia, Pennsylvania
  • Epworth Healthcare — Richmond,
  • BC Cancer - Vancouver Centre — Vancouver, British Columbia
  • Ottawa Hospital Research Institute — Ottawa,
  • University Health Network Princess Margaret Hospital — Toronto,
  • CHU de Dijon — Dijon,
  • CHRU de Lille - Hôpital Claude Huriez - Maladies du Sang — Lille,
  • Centre Lyon Berard - Medical Oncology — Lyon,
  • APHP - Hopital Saint Louis — Paris,
  • Hôpital Necker — Paris,
  • Centre Hospitalier Lyon Sud - Hématologie — Pierre-Bénite,
  • Institut Universitaire du Cancer de Toulouse-Oncopole (IUCT-Oncopole) — Toulouse,

📞 Contact the Study Coordinator

Phone: (800) 826-4673

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗